Results 81 to 90 of about 3,190,932 (313)

A Fast Algorithm for Solving a Class of the Linear Complementarity Problem in a Finite Number of Steps

open access: yesAbstract and Applied Analysis, 2020
The linear complementarity problem is receiving a lot of attention and has been studied extensively. Recently, El foutayeni et al. have contributed many works that aim to solve this mysterious problem.
Yamna Achik   +4 more
doaj   +1 more source

COVID-19 pandemic preparation: using simulation for systems-based learning to prepare the largest healthcare workforce and system in Canada

open access: yesAdvances in Simulation, 2020
Healthcare resources have been strained to previously unforeseeable limits as a result of the COVID-19 pandemic of 2020. This has prompted the emergence of critical just-in-time COVID-19 education, including rapid simulation preparedness, evaluation and ...
Mirette Dubé   +5 more
doaj   +1 more source

The chiral Hall effect in canted ferromagnets and antiferromagnets

open access: yesCommunications Physics, 2021
The Hall effect is about the generation of a transverse voltage when a longitudinal current is applied and many mechanisms can lead to Hall effect in magnetic material. Here, the authors report a chiral Hall effect that is proportional to the vector spin
Jonathan Kipp   +10 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

open access: yesMolecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir   +13 more
wiley   +1 more source

Achieving Interoperability Between Gaming Engines by Utilizing Open Simulation Standards [PDF]

open access: yes, 2023
With the increasing availability of game engines and game engine content, it is becoming more and more cost effective for new simulators to use these game engines as starting building blocks.
Garratt, W, Rithviik, S, Wang, F
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Evaluating pricing options at a museum by simulation [PDF]

open access: yes, 2014
Museums around the world make the cultural and historical artifacts available for public viewing and therefore are popular places for tourists. In this study, we present a project which was conducted for Topkapi Palace Museum (TPM) in Istanbul, Turkey ...
Günal, Murat M., Sezen, Hayrettin Kemal
core  

Simulation of the Airbus 380 evacuation [PDF]

open access: yes, 2015
A minute and a half, this is the given time to evacuate the aircraft in case of need after an emergency landing. This period is fixed no matter how many passengers are on board, no matter other considerations.
Estany de Millan, Pau   +3 more
core   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

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