Results 71 to 80 of about 3,190,932 (313)

The Brian simulator [PDF]

Frontiers in Neuroscience, 2009
"Brian" is a simulator for spiking neural networks (http://www.briansimulator.org). The focus is on making the writing of simulation code as quick and easy as possible for the user, and on flexibility: new and non-standard models are no more difficult to define than standard ones. This allows scientists to spend more time on the details of their models,
Dan F M Goodman, Dan F M Goodman, Romain Brette, Romain Brette   +3 more
openaire   +4 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Simulation-based optimization of agent scheduling in multiskill call centers. [PDF]

, 2007
We examine and compare simulation-based algorithms for solvingthe agent scheduling problem in a multiskill call center.This problem consists in minimizing the total costs of agents underconstraints on the expected service level per call type,per period ...
Gendreau, M., Athanassios N. Avramidis, Ornella Pisacane, Pisacane, O., L'Ecuyer P, Gendreau, Michel, Avramidis, Athanassios N., Michel Gendreau, L'Ecuyer, Pierre, PISACANE, ORNELLA, Pierre L’Ecuyer, L'Ecuyer, P., Avramidis A. N, Gendreau M, Avramidis, A.N.   +14 more
core  

An assessment of the effects of simulation training on management of postpartum hemorrhage: short- and long-term impact on knowledge retention, skills and teamwork in the Democratic Republic of Congo

BMC Medical Education
Background Major obstetric hemorrhage is the leading direct cause of maternal mortality throughout the world. To prevent maternal mortality, it is crucial to raise concerns regarding the knowledge and skill levels of the healthcare providers. The purpose
Jean Paul Buhendwa Cikwanine, Denis Mukwege, Justin Mongwa, Emile Mapatano shalamba, Raha Maroyi, Jonathan Tunangoya Yoyu, Ludovic Martin   +6 more
doaj   +1 more source

DIY: Creating Performance Assessments that Measure Up!

MedEdPORTAL, 2014
Introduction The demand for simulation educators to become involved in high stakes performance assessment is growing rapidly. The ability to construct reliable and valid performance assessments, and to evaluate those already available, is necessary in ...
Ann Willemsen-Dunlap, Lisa Barker, Andrew Bland, Trina Croland, John Vozenilek, Gerald Wickham   +5 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

An analysis of internal/external event ordering strategies for COTS distributed simulation [PDF]

, 2003
Distributed simulation is a technique that is used to link together several models so that they can work together (or interoperate) as a single model.
Simon J. E. Taylor, Mustafee, N, Navonil Mustafee, Taylor, SJE   +3 more
core  

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Applications of discrete-event simulation to reliability and availability assessment in civil engineering structures [PDF]

, 2009
This paper discusses the convenience of predicting, quantitatively, time-dependent reliability and availability levels associated with most building or civil engineering structures.
Monteforte, Arai, Ferrer Biosca, Albert, Juan Pérez, Ángel Alejandro, Faulin Fajardo, Francisco Javier, Serrat Piè, Carles   +4 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source