Results 71 to 80 of about 7,632,569 (355)

The role of lipid metabolism in neuronal senescence

open access: yesFEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari   +2 more
wiley   +1 more source

The Advocacy-Inquiry Rubric (AIR): a standard to build debriefing and feedback skills

open access: yesAdvances in Simulation
Background Teaching and learning debriefing and feedback skills—especially to a level of mastery—is challenging without an agreed-upon standard. There are a number of rating scales and rubrics to identify and evaluate debriefing and feedback skills that ...
Clément Buléon   +9 more
doaj   +1 more source

DIY: Creating Performance Assessments that Measure Up!

open access: yesMedEdPORTAL, 2014
Introduction The demand for simulation educators to become involved in high stakes performance assessment is growing rapidly. The ability to construct reliable and valid performance assessments, and to evaluate those already available, is necessary in ...
Ann Willemsen-Dunlap   +5 more
doaj   +1 more source

Recursive simulation and experimental frame for multiscale simulation [PDF]

open access: yes, 2009
In this paper, we present a formal and operational framework for multiscale modeling and simulation. We focus on scale transfer viewed as the coupling between two models of the same system, one at the microscopic scale and the other at the macroscopic ...
Bonte, Bruno   +3 more
core  

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

open access: yesFEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn   +4 more
wiley   +1 more source

An assessment of the effects of simulation training on management of postpartum hemorrhage: short- and long-term impact on knowledge retention, skills and teamwork in the Democratic Republic of Congo

open access: yesBMC Medical Education
Background Major obstetric hemorrhage is the leading direct cause of maternal mortality throughout the world. To prevent maternal mortality, it is crucial to raise concerns regarding the knowledge and skill levels of the healthcare providers. The purpose
Jean Paul Buhendwa Cikwanine   +6 more
doaj   +1 more source

Micromixers simulation [PDF]

open access: yes, 2009
This paper was presented at the 2nd Micro and Nano Flows Conference (MNF2009), which was held at Brunel University, West London, UK. The conference was organised by Brunel University and supported by the Institution of Mechanical Engineers, IPEM, the ...
2nd Micro and Nano Flows Conference (MNF2009)   +4 more
core  

Hybrid Simulation Safety: Limbos and Zero Crossings

open access: yes, 2017
Physical systems can be naturally modeled by combining continuous and discrete models. Such hybrid models may simplify the modeling task of complex system, as well as increase simulation performance.
EA Lee   +8 more
core   +1 more source

Simulation of Claylike Colloids [PDF]

open access: yes, 2005
We investigate properties of dense suspensions and sediments of small spherical silt particles by means of a combined Molecular Dynamics (MD) and Stochastic Rotation Dynamics (SRD) simulation.
D. J. Shaw   +15 more
core   +2 more sources

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

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