Results 91 to 100 of about 3,180,639 (313)

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Online Text-based Roleplay-Simulation: The Challenges Ahead [PDF]

, 2005
Online Roleplay-Simulation has widely been shown to be an effective teaching and learning tool based on participant feedback. Central to achieving the desired learning outcomes from these activities is the way communication media is used within them. The
McLaughlan, RG, Kirkpatrick, D
core  

Simulation Study of Corrosion Product Removal Behavior by Mixed-Bed Ion Exchange Columns in PWRs

Science and Technology of Nuclear Installations
In order to reduce the negative impact of corrosion products on the operation of pressurized water reactors (PWRs) and to provide support for the operation and failure analysis of the purification resin in the first circuit of the PWRs, this paper takes ...
Shiyu Tan, Haiyan Xie, Shuang Chen, Ke Wang, Shitao Liu, Dongyun Li, Jing Li, Yang Gao, Hongguo Hou, Caishan Jiao, Nan Chao, Tingting Liu, Yu Zhou   +12 more
doaj   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Simulation-based optimization of agent scheduling in multiskill call centers.

, 2007
We examine and compare simulation-based algorithms for solvingthe agent scheduling problem in a multiskill call center.This problem consists in minimizing the total costs of agents underconstraints on the expected service level per call type,per period ...
Gendreau, M., Athanassios N. Avramidis, Ornella Pisacane, Pisacane, O., L'Ecuyer P, Gendreau, Michel, Avramidis, Athanassios N., Michel Gendreau, L'Ecuyer, Pierre, PISACANE, ORNELLA, Pierre L’Ecuyer, L'Ecuyer, P., Avramidis A. N, Gendreau M, Avramidis, A.N.   +14 more
core  

Simulating Counterfactuals

Journal of Artificial Intelligence Research
Counterfactual inference considers a hypothetical intervention in a parallel world that shares some evidence with the factual world. If the evidence specifies a conditional distribution on a manifold, counterfactuals may be analytically intractable. We present an algorithm for simulating values from a counterfactual distribution where conditions can be
Karvanen Juha, Vihola Matti, Tikka Santtu   +2 more
openaire   +3 more sources

Intelligent Tutoring Systems for Adult Learning in STEM Disciplines

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Intelligent tutoring systems (ITS) are reshaping adult learning in STEM by providing adaptive, data‐driven instruction across classrooms, workplaces, and informal environments. In the context of ITS, this article compares generative AI, which creates personalized explanations and practice materials, with explainable AI, which focuses on ...
Jill Zarestky, Amanda R. Lager Gleason
wiley   +1 more source

An analysis of internal/external event ordering strategies for COTS distributed simulation

, 2003
Distributed simulation is a technique that is used to link together several models so that they can work together (or interoperate) as a single model.
Simon J. E. Taylor, Mustafee, N, Navonil Mustafee, Taylor, SJE   +3 more
core  

Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende, Emilien Petit, Young Woo Park, Sophie Tezenas du Montcel, James M. Joers, Jonathan M. DuBois, H. Moore Arnold, Michal Povazan, Ipek Özdemir, Guita Banan, Romain Valabregue, Philipp Ehses, Jennifer Faber, Chiadi U. Onyike, Peter B. Barker, Jeremy D. Schmahmann, Eva‐Maria Ratai, Sub H. Subramony, Thomas H. Mareci, Khalaf O. Bushara, Henry Paulson, Thomas Klockgether, Alexandra Durr, Tetsuo Ashizawa, Christophe Lenglet, Gülin Öz, READISCA Investigators   +26 more
wiley   +1 more source

Applications of discrete-event simulation to reliability and availability assessment in civil engineering structures

, 2009
This paper discusses the convenience of predicting, quantitatively, time-dependent reliability and availability levels associated with most building or civil engineering structures.
Monteforte, Arai, Ferrer Biosca, Albert, Juan Pérez, Ángel Alejandro, Faulin Fajardo, Francisco Javier, Serrat Piè, Carles   +4 more
core   +1 more source