Results 51 to 60 of about 3,180,639 (313)

Technological trends in wheeled armoured vehicle from patent analysis

open access: yes선진국방연구, 2023
This study analyzed the domestic and foreign patent applications and technology trends of wheeled armored vehicles. Patents for wheeled armored vehicles have been steadily filed since 2009. As the technology development of armoured vehicles has achieved
Jina Kwon   +3 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

open access: yesMolecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi   +7 more
wiley   +1 more source

Performance, Validation and Testing with the Network Simulation Cradle

open access: yes, 2006
Much current simulation of TCP makes use of simplified models of TCP, which is a large and complex protocol with many variations possible between implementations.
Jansen, Sam, McGregor, Anthony James
core   +1 more source

Outreach simulation for system improvement: a novel advocacy and reporting process

open access: yesAdvances in Simulation
Introduction Healthcare simulation programmes measuring their value risk wasting resources in attempts to prove they impact patient outcomes. Simulation is one of many strategies used to enhance healthcare systems, and proving specific correlation with ...
A. St-Onge-St-Hilaire   +5 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Simulation as an intuition building tool for factory physics

open access: yes, 2007
In today's manufacturing environment it is absolutely critical to be competitive in order to guarantee a company's sustainability. One way to achieve this sustainability is to count on management's ability to effectively make decisions dealing with its ...
González Gómez, José Arturo   +1 more
core   +1 more source

The Advocacy-Inquiry Rubric (AIR): a standard to build debriefing and feedback skills

open access: yesAdvances in Simulation
Background Teaching and learning debriefing and feedback skills—especially to a level of mastery—is challenging without an agreed-upon standard. There are a number of rating scales and rubrics to identify and evaluate debriefing and feedback skills that ...
Clément Buléon   +9 more
doaj   +1 more source

The Brian simulator [PDF]

open access: yesFrontiers in Neuroscience, 2009
"Brian" is a simulator for spiking neural networks (http://www.briansimulator.org). The focus is on making the writing of simulation code as quick and easy as possible for the user, and on flexibility: new and non-standard models are no more difficult to define than standard ones. This allows scientists to spend more time on the details of their models,
Dan F M Goodman   +3 more
openaire   +4 more sources

MITF maintains genome stability in nonmelanocyte lineages

open access: yesMolecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir   +13 more
wiley   +1 more source

Industrial Implementation of AM : Why is it still so slow? What is the role of simulation?

open access: yes, 2021
Some aspecs of industrializing Additive Manufacturing are discussed with a special focus on the role of numerical manufacturing process ...
Telgkamp, Jens
core  

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