Results 31 to 40 of about 3,180,639 (313)
Biotite: new tools for a versatile Python bioinformatics library
BMC Bioinformatics, 2023 Background Biotite is a program library for sequence and structural bioinformatics written for the Python programming language. It implements widely used computational methods into a consistent and accessible package.
Patrick Kunzmann +7 more
doaj +1 more source
Qualitative evaluation of asthma services for young people: a sequential simulation study
, 2020 Background Asthma is the most common chronic disease of childhood and an important preventable cause of mortality in children and young people (CYP). Few studies have brought together CYP and health professionals to understand the patient perspective of ...
McGeorge, Elizabeth +6 more
core +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Semiautomatic generation of Web courses by means of an object-oriented simulation language [PDF]
, 1999 This paper describes the procedure we have used to semiautomatically generate three different courses for the web. The simulation used in these courses have been written in our special-purpose object-oriented continuous simulation language (OOCSMP).
Alfonseca Moreno, Manuel +2 more
core +1 more source
Theoretical Computer Science, 2010 Boolean notions of correctness are formalized by preorders on systems. Quantitative measures of correctness can be formalized by real-valued distance functions between systems, where the distance between implementation and specification provides a measure of “fit” or “desirability.” We extend the simulation preorder to the quantitative setting, by ...
Cerný +3 more
openaire +2 more sources
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Epistemology of modeling and simulation
, 2013 While ontology deals with the question of being or existence, epistemology deals with the question of gaining knowledge. This panel addresses the challenge of how we gain knowledge from modeling and simulation.
Tolk, A. +17 more
core +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Accuracy of maxillary segmental osteotomy using 3D simulation: A case report [PDF]
, 2015 To overcome limitations of conventional diagnosis and planning for orthognathic surgery, surgeons have begun to use 3-dimensional (3D) virtual simulation to plan complex orthognathic surgery. In many literatures, it has shown that better surgical outcome
여기성 +3 more
core +1 more source