Results 41 to 50 of about 7,724,023 (291)

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

DIY: Creating Performance Assessments that Measure Up!

MedEdPORTAL, 2014
Introduction The demand for simulation educators to become involved in high stakes performance assessment is growing rapidly. The ability to construct reliable and valid performance assessments, and to evaluate those already available, is necessary in ...
Ann Willemsen-Dunlap, Lisa Barker, Andrew Bland, Trina Croland, John Vozenilek, Gerald Wickham   +5 more
doaj   +1 more source

Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias, Ana Oitabén, Sonia Zumalave, Bernardo Rodriguez‐Martin, María Gallardo‐Gómez, Martín Santamarina, Ana Pequeño‐Valtierra, Laura Juaneda‐Magdalena, Ramón García‐Escudero, José Luis López‐Cedrún, Máximo Fraga, José M. C. Tubio, Mónica Martínez‐Fernández   +12 more
wiley   +1 more source

Outreach simulation for system improvement: a novel advocacy and reporting process

Advances in Simulation
Introduction Healthcare simulation programmes measuring their value risk wasting resources in attempts to prove they impact patient outcomes. Simulation is one of many strategies used to enhance healthcare systems, and proving specific correlation with ...
A. St-Onge-St-Hilaire, B. Lawton, L. Dodson, J. Acworth, D. Hufton, B. Symon   +5 more
doaj   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

The Advocacy-Inquiry Rubric (AIR): a standard to build debriefing and feedback skills

Advances in Simulation
Background Teaching and learning debriefing and feedback skills—especially to a level of mastery—is challenging without an agreed-upon standard. There are a number of rating scales and rubrics to identify and evaluate debriefing and feedback skills that ...
Clément Buléon, Demian Szyld, Robert Simon, Lon Setnik, Walter J. Eppich, Mary Fey, James A. Lipshaw, Janice C. Palaganas, Jenny W. Rudolph, Advocacy Inquiry Interest Group   +9 more
doaj   +1 more source

The atomic simulation environment-a Python library for working with atoms.

Journal of Physics: Condensed Matter, 2017
The atomic simulation environment (ASE) is a software package written in the Python programming language with the aim of setting up, steering, and analyzing atomistic simulations. In ASE, tasks are fully scripted in Python.
Ask Hjorth Larsen, Jens Jørgen Mortensen, J. Blomqvist, I. Castelli, R. Christensen, M. Dulak, J. Friis, M. Groves, B. Hammer, Cory Hargus, E. Hermes, P. C. Jennings, Peter Bjerre Jensen, J. Kermode, J. Kitchin, Esben Leonhard Kolsbjerg, J. Kubal, K. Kaasbjerg, S. Lysgaard, Jón Bergmann Maronsson, Tristan Maxson, T. Olsen, L. Pastewka, Andrew A. Peterson, C. Rostgaard, J. Schiøtz, O. Schütt, M. Strange, K. Thygesen, T. Vegge, L. Vilhelmsen, M. Walter, Z. Zeng, K. Jacobsen   +33 more
semanticscholar   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

An assessment of the effects of simulation training on management of postpartum hemorrhage: short- and long-term impact on knowledge retention, skills and teamwork in the Democratic Republic of Congo

BMC Medical Education
Background Major obstetric hemorrhage is the leading direct cause of maternal mortality throughout the world. To prevent maternal mortality, it is crucial to raise concerns regarding the knowledge and skill levels of the healthcare providers. The purpose
Jean Paul Buhendwa Cikwanine, Denis Mukwege, Justin Mongwa, Emile Mapatano shalamba, Raha Maroyi, Jonathan Tunangoya Yoyu, Ludovic Martin   +6 more
doaj   +1 more source

COVID-19 pandemic preparation: using simulation for systems-based learning to prepare the largest healthcare workforce and system in Canada

Advances in Simulation, 2020
Healthcare resources have been strained to previously unforeseeable limits as a result of the COVID-19 pandemic of 2020. This has prompted the emergence of critical just-in-time COVID-19 education, including rapid simulation preparedness, evaluation and ...
Mirette Dubé, Alyshah Kaba, Theresa Cronin, Sue Barnes, Tara Fuselli, Vincent Grant   +5 more
doaj   +1 more source