Results 31 to 40 of about 672,616 (313)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Building pedestrian simulation and channel design simulation technology based on virtual reality technology [PDF]

Archives of Civil Engineering
In recent years, virtual reality technology has been widely applied and researched in various fields. In digital architectural design and simulation, it has gradually become an important tool.
Xiangling Luo, Mingyang Liu
doaj   +1 more source

Simulation Based Design of Automotive Systems [PDF]

, 1993
The design of automotive systems using simulation tools features cost reduction and quality enhancement. This paper presents two basic approaches. The rust approach deals with the application of CAD data bases to the evaluation of input data for multibody system formalisms, most adequate for automotive system modeling. An object oriented data model for
openaire   +2 more sources

Design of a Simulation Framework for Model-based Learning

Proceedings of the 4th International Conference on Model-Driven Engineering and Software Development, 2016
In model-driven learning, simulation of Business Process is a key step for improving the learners's skills and enhancing teaching performance. In this paper, we provide the architectural design and the main functionalities of a model-based learning simulation framework. The main objectives of the proposed framework are: i) enable user-friendly learning
Zribi S., Calabro' A., Lonetti F., Marchetti E., Jorquera T., Lorré J.   +5 more
openaire   +2 more sources

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Design of a Broadband Transition from a Coaxial Cable to a Reduced-Height Rectangular Waveguide

Applied Sciences, 2023
For miniaturization, rectangular waveguides with a reduced height are often required, along with a coaxial transition for signal launching. We present a simulation-based design of a broadband transition from a coaxial cable to a rectangular waveguide ...
Bayarsaikhan Dansran, Songyuan Xu, Jiwon Heo, Chan-Soo Lee, Bierng-Chearl Ahn   +4 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Combining Axiomatic Design and Case-Based Reasoning in a Design Methodology of Mechatronics Products [PDF]

, 2009
Organised by: Cranfield UniversityCurrent market environments are volatile and unpredictable. The ability for design products to meet customer’s requirements has become critical to success.
Janthong, N., Brissaud, D., Janthong, Nattawut, Butdee, S., Butdee, Suthep, Brissaud, Daniel   +5 more
core  

Innovative Acoustic Treatments of Nacelle Intakes Based on Optimised Metamaterials

Aerospace, 2021
Modern turbofans with high bypass ratios, low blade passage frequencies and short nacelles require continuous development of acoustic linings to achieve the noise reductions expected by the international aviation authorities. Metamaterials and metafluids
Giorgio Palma, Lorenzo Burghignoli, Francesco Centracchio, Umberto Iemma   +3 more
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source