Results 41 to 50 of about 672,616 (313)

Structural Design Using Simulation Based Reliability Assessment

Acta Polytechnica, 2001
The concept of Simulation Based Reliability Assessment (SBRA) for Civil Engineering structures is presented. SBRA uses bounded histograms to represent variable material and geometric properties as well as variable load effects, and makes use of the Monte
S. Vukazich, P. Marek
doaj  

Design Framework for Motion Generation of Planar Four-Bar Linkage Considering Clearance Joints and Dynamics Performance

Machines, 2022
In this paper, we present a novel design framework to connect linkage synthesis with dynamics performance of the linkage. The aim of the design framework is to improve the dynamics performance of the mechanism through linkage design, instead of improving
Xueao Liu, Jianzhong Ding, Chunjie Wang
doaj   +1 more source

The Design Projects for the Simulation-Based Design Course [PDF]

2016 ASEE Annual Conference & Exposition Proceedings, 2016
The Design Projects for the Simulation Based Design Course The course MECH625-simulation-based design in our program was mainly to conduct FEA (Finite Element Analysis) on components and assemblies to provide stress/strain information. Through our program assessment, it was found that students who performed excellently in the previous MECH625 course ...
Xiaobin Le P.E., Ali Reza Moazed, Anthony William Duva P.E.   +2 more
openaire   +2 more sources

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

The rapid design of simulation models using cladistics and template based modelling [PDF]

, 2012
The drive towards a more globally competitive market has led to an increase in demand for goods and services on a global scale. As a result of this increase in productivity, production systems are being designed and redesigned at an increased rate and ...
Rampersad, Kevin
core  

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Automatic Optimization of Air Conduct Design Using Experimental Data and Numerical Results [PDF]

International Journal for Simulation and Multidisciplinary Design Optimization, 2010
The development of a new product is a process that goes through several phases, each of them requiring the ca- pitalization of data, information, knowledge and experiences gathered from previous projects.
Toussaint Luis, Lebaal Nadhir, Schlegel Daniel, Gomes Samuel   +3 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Interactive space generation through play: exploring the role of simulation on the design table [PDF]

, 2005
In this paper we report on recent developments in the use of simulation as an aspect of design decision support for architecture and planning. This research is based on ARTHUR (Augmented Round Table for Architecture and Urban Planning).
F. Aish, W. Broll, J. Ohlenburg, A. Strothmann, C. Mottram, Fatah gen. Schieck, A., Attfield, S., A. Penn, Mottram, C., Ohlenburg, J., S. Attfield, Broll, W., Penn, A., A. Schieck, Aish, F.   +14 more
core  

Simulation‐Based Material Design for HVDC Cable Accessories

High Voltage
The worldwide increasing demand for electricity, coupled with the need for more reliable infrastructures and more interconnected networks, has put forward high voltage direct current (HVDC) technologies for energy transmissions.
Thi Thu Nga Vu, Gilbert Teyssèdre, Séverine Le Roy   +2 more
doaj   +1 more source