Results 61 to 70 of about 672,616 (313)

Analysis and Simulation on Energy Performance Based Design

Megaron, 2011
The definition of sustainability varies depending on the sector to which it is related. In the building sector, sustainability mainly covers “high performance building” requirements.
Gülsu ULUKAVAK HARPUTLUGİL
doaj  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Simulation-Based Education to Improve Hand Hygiene Practices: A Pilot Study in Sub-Saharan Africa

Hygiene
Hand hygiene is a key measure to prevent healthcare-associated infections (HAIs), yet compliance remains low in Sub-Saharan Africa (SSA), due to limited resources, insufficient training, and behavioral challenges.
Paula Rocha, Stephanie Norotiana Andriamiharisoa, Ana Catarina Godinho, Pierana Gabriel Randaoharison, Lugie Harimalala, Lova Narindra Randriamanantsoa, Oni Zo Andriamalala, Emmanuel Guy Raoelison, Jane Rogathi, Paulo Kidayi, Christina Mtuya, Rose Laisser, Eyeshope J. Dausen, Pascalina Nzelu, Barbara Czech-Szczapa, Edyta Cudak-Kasprzak, Marlena Szewczyczak, João Graveto, Pedro Parreira, Sofia Ortet, M. Rosário Pinto   +20 more
doaj   +1 more source

Design and simulation of gear transmission system based on metamaterial

AIP Advances, 2023
In this research, we integrate a three-dimensional micro-/nano-lattice structure metamaterial with conventional helical gears using a composite method to reduce the vibration.
Shuihai Dou, Yuxin Liu, Yanping Du, Zhaohua Wang, Juncheng Tu, Zhaoyong Sun   +5 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Simulation based design tool for radial turbine rotors

Journal of Engineering and Applied Science
Radial turbines are critical components in turbocharging systems, where improvements in aerodynamic efficiency directly enhance energy utilization. This work presents an integrated optimization framework that combines reduced-order one-dimensional (1D ...
Mostafa Abdo Fawaz, Ahmed Farid Ayad, Mohammed Shaheen, Hesham Mahmoud, Al-samieh M. F.   +4 more
doaj   +1 more source

The 2024 French guidelines for scenario design in simulation-based education: manikin-based immersive simulation, simulated participant-based immersive simulation and procedural simulation

Medical Education Online
Background Simulation-based education in healthcare encompasses a wide array of modalities aimed at providing realistic clinical experiences supported by meticulously designed scenarios. The French-speaking Society for Simulation in Healthcare (SoFraSimS)
Guillaume Der Sahakian, Maxime de Varenne, Clément Buléon, Guillaume Alinier, Christian Balmer, Antonia Blanié, Bertrand Bech, Anne Bellot, Hamdi Boubaker, Nadège Dubois, Francisco Guevara, Erwan Guillouet, Jean-Claude Granry, Morgan Jaffrelot, François Lecomte, Fernande Lois, Mohammed Mouhaoui, Ollivier Ortolé, Méryl Paquay, Justine Piazza, Marie Pittaco, Patrick Plaisance, Dan Benhamou, Gilles Chiniara, Etienne Rivière   +24 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Simulation of Reactive Fluoropolymer-Based Material Penetrator

It is very important to solve the numerical simulation of fluoropolymer-based reactive materials in the process of engineering design. Although custom development techniques are rapidly being applied to numerical simulation problems of reactive materials,
Peiyu Li, Mengmeng Guo, Qingbo Yu, Zhenyang Liu, Jiahao Zhang   +4 more
core   +1 more source

Object-Oriented Simulation Model Generation in an Automated Control Software Development Framework [PDF]

, 2009
Organised by: Cranfield UniversityThe automated development of control software for mechatronic systems requires the integration of control models for design and verification purposes.
van Tooren, M. J. L., Foeken, M. J.
core