Results 41 to 50 of about 898,870 (314)
Conceptual simulation design [PDF]
The work presented in this thesis considers the issues related to the design and implementation of the rotor blade production facility at Rolls-Royce.
Ochwa, Michael O,
core
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Design of a Virtual Articulator for the Simulation and Analysis of Mandibular Movements in Dental CAD/CAM [PDF]
Organised by: Cranfield UniversityThis paper presents a research project aiming at designing a Virtual Articulator in order to simulate and analyze mandibular movements of the human jaw.
Muniozguren, J. +4 more
core
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson +6 more
wiley +1 more source
Graphene-based functionalized materials can serve diversified range of applications. It has 2D honeycomb-like structure. Oxygenated functional groups of graphene oxide (GO) can be eliminated to obtain reduced graphene oxide (RGO), which generally ...
Subir Podder +2 more
doaj +1 more source
To reduce the computing resource of full-scale impedance matrix and its high-order derivatives in traditional Asymptotic Waveform Evaluation (AWE), compressive sensing (CS) is applied to AWE for fast and accurate frequency-sweep analysis of ...
Meng Kong +3 more
doaj +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
A porous 3D cross-linked conductive network pierced by multi-wall carbon nanotubes (MWCNTs) was successfully designed from zeolitic imidazolate framework-8 (ZIF-8).
Shi-bin Lu +9 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source

