Results 61 to 70 of about 898,870 (314)

Design and discrete event simulation of power and free handling systems [PDF]

, 1997
Effective manufacturing systems design and implementation has become increasingly critical, with the reduction in manufacturing product lead times, and the subsequent influence on engineering projects.
Lynn, Jeffrey Alexander
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Design project planning, monitoring and re-planning through process simulation

, 2009
Effective management of design schedules is a major concern in industry, since timely project delivery can have a significant influence on a company’s profitability.
P John Clarkson, David C Wynn
core  

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Modelling iteration in engineering design

, 2007
This paper examines design iteration and its modelling in the simulation of New Product Development (NPD) processes. A framework comprising six perspectives of iteration is proposed and it is argued that the importance of each perspective depends upon ...
Eckert, C. M., Wynn, D. C., Clarkson, P. J.   +2 more
core  

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Designing of a volcano simulator

, 2010
Peer ...
Cadena Muñoz, Francisco Javier, Manuel Lázaro, Antonio, Río Fernández, Joaquín del, Martí Molist, Joan, Geyer Traver, Adelina, Molino Minero, Erik   +5 more
openaire   +2 more sources

Business success through process based application of simulation

, 2008
Progressive design practices are increasingly cognisant of the potential of building energy simulation to assist the delivery of energy efficient, sustainable buildings.
Cockroft, Jeremy, McElroy, L.B., Hand, Jon, McElroy, Lori, Hand, J., Cockroft, J.   +5 more
core  

Interactive space generation through play: exploring the role of simulation on the design table [PDF]

, 2005
In this paper we report on recent developments in the use of simulation as an aspect of design decision support for architecture and planning. This research is based on ARTHUR (Augmented Round Table for Architecture and Urban Planning).
F. Aish, W. Broll, J. Ohlenburg, A. Strothmann, C. Mottram, Fatah gen. Schieck, A., Attfield, S., A. Penn, Mottram, C., Ohlenburg, J., S. Attfield, Broll, W., Penn, A., A. Schieck, Aish, F.   +14 more
core  

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source