Results 71 to 80 of about 898,870 (314)

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

open access: yesFEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn   +4 more
wiley   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

open access: yesFEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth   +6 more
wiley   +1 more source

Energy efficiency enhancement in two European data centers through CFD modeling

open access: yesScientific Reports
The new reporting scheme adopted by the European Union focuses on the efficiency assessment of data centers based on key performance indicators (KPIs).
Onur Muhammed Sarikaya   +7 more
doaj   +1 more source

Building pedestrian simulation and channel design simulation technology based on virtual reality technology [PDF]

open access: yesArchives of Civil Engineering
In recent years, virtual reality technology has been widely applied and researched in various fields. In digital architectural design and simulation, it has gradually become an important tool.
Xiangling Luo, Mingyang Liu
doaj   +1 more source

Lap time simulation for racing car design [PDF]

open access: yes, 2002
Racing teams use numerous computational tools (CAD, FEA, CFD) to aid in the design of racing cars and the development of their performance. Computer simulation of racing car handling through Lap Time Simulation (LTS) packages complements these tools. It
Siegler, Blake
core  

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

open access: yesFEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman   +4 more
wiley   +1 more source

Building systems and indoor environment : simulation for design decision support

open access: yes, 2001
This paper outlines the state-of-the-art in integrated building simulation for design support. The ESP-r system is used as an example where integrated simulation is a core philosophy behind the development.
Hensen, J.   +2 more
core  

Simulation of Reactive Fluoropolymer-Based Material Penetrator

open access: yes
It is very important to solve the numerical simulation of fluoropolymer-based reactive materials in the process of engineering design. Although custom development techniques are rapidly being applied to numerical simulation problems of reactive materials,
Peiyu Li   +4 more
core   +1 more source

RF Electronics: design and simulation [PDF]

open access: yes, 2013
[Extract] The material presented in this book evolved from teaching analogue electronics courses at James Cook University over many years. When I started teaching electronics design, computer simulation tools were non-existent and most of the design ...
Kikkert, Cornelius J.
core  

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

open access: yesFEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui   +10 more
wiley   +1 more source

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