Results 81 to 90 of about 5,438,311 (249)

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Fixed point results employing simulation functions in JS-metric spaces

open access: yesFixed Point Theory and Algorithms for Sciences and Engineering
This paper introduces a new class of contractions in JS-metric spaces and utilizes it to obtain fixed point results, which generalize several well-known results. Moreover, an example is given to illustrate the utility of the obtained results.
Based Ali   +2 more
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

open access: yesFEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong   +3 more
wiley   +1 more source

A Simulation of Human Heart Function

open access: yesBiophysical Journal, 1973
A simulation of the function of the human heart and heart muscle has been developed in the form of a digital computer code. For a given set of values for the input variables, realistic values of the cardiac output variables are predicted. A detailed discussion of the simulation and some results obtained from its application are presented.
openaire   +2 more sources

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

open access: yesFEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard   +12 more
wiley   +1 more source

Constructing a spreadsheet simulation model of Chuck-a-luck: An application of logical functions

open access: yesSpreadsheets in Education, 2004
Chuck-a-luck is an inviting game played at carnivals in the Midwestern United States and England. A player picks a number from 1 to 6 and an operator rolls three dice.
Fred J Rispoli
doaj   +2 more sources

Application of Ventsim 3D ventilation simulation system in Sitai Mine

open access: yesGong-kuang zidonghua, 2015
In view of problems of complex ventilation system, difficult management and adjustment of ventilation system according to experience existed in Sitai Mine, Ventsim 3D ventilation simulation system was applied to build 3D ventilation network model, which ...
XING Yanbing
doaj   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

open access: yesFEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro   +1 more
wiley   +1 more source

Simulating Quantum Computation: How Many “Bits” for “It”?

open access: yesPRX Quantum
A recently introduced classical simulation method for universal quantum computation with magic states operates by repeated sampling from probability functions [M. Zurel et al. PRL 260404 (2020)].
Michael Zurel   +2 more
doaj   +1 more source

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