Results 31 to 40 of about 15,112,343 (251)

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Efficient Simulation of LWD Azimuthal Propagation Resistivity Tool in Layered TI Formation Based on 3-D Finite Volume Method of Coupled Potentials in the Half Space and Continuation Technique

IEEE Access
In this paper, we improve the three-dimensional (3-D) finite volume algorithm of coupled potentials on cylindrical grids to enhance the simulation efficiency of the logging while drilling (LWD) azimuthal propagation resistivity tool (APR).
Haosen Wang, Shouwen Yang, Hongnian Wang
doaj   +1 more source

Spectral Dynamic Analysis of A Stationary Jack-Up Platform

Polish Maritime Research, 2019
The paper refers to the dynamic short-term response analysis of the Baltic steel drilling platform (see Fig.2) in a random sea-state represented by one-dimensional wave spectrum proposed by Striekalov and Massel, which is recommended for the Baltic Sea ...
Rozmarynowski Bogdan
doaj   +1 more source

Analiza efekata uvođenja savremenih strategija održavanja / Effects of introducing modern maintenance strategies and their analysis [PDF]

Vojnotehnički Glasnik, 2003
Često se postavlja pitanje opravdanosti investicija za unapređivanje sistema održavanja. Uvođenje strategija održavanja, kao što su RCM, TPM, održavanje prema stanju i sličnih, danas je svetski trend u usavršavanju sistema održavanja.
Petar Stanojević
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Unlocking the power of orbital-free density functional theory to explore the electronic structure under extreme conditions [PDF]

Matter and Radiation at Extremes
Recent advances in X-ray free-electron laser diagnostics have enabled direct probing of electronic properties under extreme pressures and temperatures, such as those encountered in stellar interiors and inertial confinement fusion experiments ...
Cheng Ma, Qiang Xu, Zhenhao Zhang, Ke Wang, Ying Sun, Wenhui Mi, Zhandos A. Moldabekov, Tobias Dornheim, Jan Vorberger, Sebastian Schwalbe, Xuecheng Shao   +10 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Massive open online course: a new strategy for faculty development needs in healthcare simulation

Advances in Simulation
Faculty development in medical simulation is a growing need, given the increased use of simulation-based learning in healthcare. Training of trainers is demanding and resource-consuming; therefore, there is a need for accessible, practical, and resource ...
Nadège Dubois, Céline Tonus, Sophie Klenkenberg, Anne-Françoise Donneau, Clément Buléon, Alexandre Ghuysen   +5 more
doaj   +1 more source

In Situ Simulation [PDF]

, 2020
Introduction Working under extreme stress can cause medical professionals to deviate from clinical guidelines even if they know of their existence, let alone in situations such as COVID-19 where guidelines are unclear, fluid, and resources limited.
Rim Banat, Joe Fayad, Zeineddine, Rida, Fayad, Joe, Rana Sharara-Chami, Sabouneh, Rami, Banat, Rim, Lakissian, Zavi, Sharara-Chami, Rana I., Zavi Lakissian, Rami Sabouneh, Rida Zeineddine   +11 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source