Results 41 to 50 of about 15,112,343 (251)
Theory-oriented evaluation for the design of and research in gaming and simulation [PDF]
, 2006 Jan Klabbers introduced the terms science of analysis and science of design to indicate differences between the communities of theoretical research with gaming simulation and the game design practitioners.
Hense, Jan Ulrich +2 more
core +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
The Influence of Physical Properties of C55 Alloy on Geometry of Flow in the Process of Shaping [PDF]
Archives of Metallurgy and MaterialsThe paper presents analysis of influence of change of physical parameters such as: temperature, friction coefficient and load, during the process of die forging.
M. Nabrdalik, M. Sobociński
doaj +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Mathematical Models for Named Data Networking Producer Mobility Techniques: A Review
MathematicsOne promising paradigm for content-centric communication is Named Data Networking (NDN), which revolutionizes data delivery and retrieval. A crucial component of NDN, producer mobility, presents new difficulties and opportunities for network optimization.
Wan Muhd Hazwan Azamuddin +4 more
doaj +1 more source
Economic modelling under conditions of exploitation of cohesive construction minerals
Acta Universitatis Agriculturae et Silviculturae Mendelianae Brunensis, 2011 Managers of mining companies use for decision-making on optimization of manufacturing processes advanced modelling methods and simulations on computers.
Milan Mikoláš +4 more
doaj +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Prediction of Room‐Temperature Superconductivity in Quasi‐Atomic H2‐Type Hydrides at High Pressure
Advanced ScienceAchieving superconductivity at room temperature (RT) is a holy grail in physics. Recent discoveries on high‐Tc superconductivity in binary hydrides H3S and LaH10 at high pressure have directed the search for RT superconductors to compress hydrides with ...
Qiwen Jiang +7 more
doaj +1 more source
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source