Results 101 to 110 of about 586,656 (316)

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

A Physical Model of a Single-Reed Wind Instrument, Including Actions of the Player [PDF]

, 2003
For the Physical Modeling Synthesis of wind instruments, we choose to design a model adapted to time domain simulation which takes into account the main part of the physical phenomena, including instrument/player interactions.
DUCASSE, Eric
core   +1 more source

Development of a Joint Tumor Size–Overall Survival Modeling and Simulation Framework Supporting Oncology Development Decision‐Making

CPT: Pharmacometrics & Systems Pharmacology
Tumor size–overall survival (TS‐OS) models can support decision‐making in oncology drug development by predicting long‐term OS based on TS data from early data cuts and baseline patient factors.
Herbert Struemper, Chetan Rathi, Morris Muliaditan, Sebastiaan C. Goulooze, Richard C. Franzese, Alejandro Mantero, Murad Melhem, Teun M. Post, Sandra A. G. Visser   +8 more
doaj   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Discovery and Reuse of Modeling and Simulation Assets / Paper 09S-SIW-076 [PDF]

, 2009
Simulation Interoperability Standards Organization (SISO) SIW Conference PaperThe ability to discover existing modeling and simulation (M&S) assets is a critical need for enabling effective reuse and for reducing the duplication of capabilities.
Blais, Curtis, Scrudder, Roy, Gustavson, Paul, Nikolai, Ali, Daehler-Wilking, Richard   +4 more
core  

Tutorial on Conditional Simulations With a Tumor Size‐Overall Survival Model to Support Oncology Drug Development

CPT: Pharmacometrics & Systems Pharmacology
The gold standard for regulatory approval in oncology is overall survival (OS). Because OS data are initially limited, early drug development decisions are often based on early efficacy endpoints, such as objective response rate and progression‐free ...
Sebastiaan C. Goulooze, Morris Muliaditan, Richard C. Franzese, Alejandro Mantero, Sandra A. G. Visser, Murad Melhem, Teun M. Post, Chetan Rathi, Herbert Struemper   +8 more
doaj   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Extensible Modeling and Simulation Framework (XMSF) challenges for web-based modeling and simulation [PDF]

, 2002
Findings and recommendations report: Technical Challenges Workshop, Strategic Opportunities Symposium 22 October 2002The Department of Defense (DoD) is engaged in warfighting and institutional transformation for the new millennium.
Fouskarinis, Steven, Morse, Katherine L., Drake, David, McGregor, Don, Blais, Curt, Brutzman, Don, Pullen, J. Mark, Moen, Dennis, Zyda, Michael, Kapolka, Andrzej   +9 more
core  

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source