Results 81 to 90 of about 586,656 (316)

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

A multistate platform model for time‐to‐event endpoints in oncology clinical trials

CPT: Pharmacometrics & Systems Pharmacology
A multistate platform model was developed to describe time‐to‐event (TTE) endpoints in an oncology trial through the following states: initial, tumor response (TR), progressive disease (PD), overall survival (OS) event (death), censor to the last ...
Chih‐Wei Lin, Mario Nagase, Sameer Doshi, Sandeep Dutta   +3 more
doaj   +1 more source

Simulation modeling and methodology [PDF]

ACM SIGSIM Simulation Digest, 1977
Simulation is one of the most powerful analysis tools available to those responsible for the design and/or operation of complex processes or systems. It is heavily based upon computer science, mathematics, probability theory and statistics: yet the process of simulation modeling and experimentation remains very much an intuitive art.
openaire   +2 more sources

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Cloud Computing for Simulation in Manufacturing and Engineering: Introducing the CloudSME Simulation Platform

, 2014
There are many benefits of implementing simulation software on a Cloud. These include the use of scalable, on-demand access to resources that can be used to speed up simulation and the development of composable Modeling & Simulation services (Modeling ...
Kiss, T., Terstyanszky, G., Taylor, S.J.E., Fantini, N., Kacsuk, P.   +4 more
core  

Command and Control System to Simulation System Interoperation: Development of the C2SIM Standard [PDF]

, 2019
SISO 2019-SIWDocuments include Paper & Presentation.Simulation Interoperability Standards Organization (SISO) SIW Conference PaperA Simulation Interoperability Standards Organization (SISO) Product Development Group (PDG) is developing a standard for ...
Reece, Douglas, Corner, Douglas, Blais, Curtis, Pullen, Mark, Singapogu, Samuel   +4 more
core  

Mathematical modeling of Echinococcosis in humans, dogs and livestock with optimal control strategies [PDF]

Iranian Journal of Numerical Analysis and Optimization
In this paper, we present a deterministic model of Cystic Echinococcosis disease of eleven differential equations, describing complex interactions between three types of hosts, specifically humans, livestock and dogs.
I. Sannaky, M. Riouali, N. Ouldkhouia, I. El berrai, K. Adnaoui   +4 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Integration of Time‐Varying Pharmacometric Modeling With Cox Regression for Time‐to‐Event Analysis in NONMEM

CPT: Pharmacometrics & Systems Pharmacology
Although time‐varying Cox regression modeling approaches have been developed, exposure–response analyses for time‐to‐event (TTE) endpoints often rely on static exposure covariates and may overlook the real‐world dosing variability and drug concentration ...
Chih‐Wei Lin, Po‐Wei Chen, Sameer Doshi, Sandeep Dutta   +3 more
doaj   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source