Results 71 to 80 of about 586,656 (316)
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Interdomain I/O Optimization in Virtualized Sensor Networks
Sensors, 2018 In virtualized sensor networks, virtual machines (VMs) share the same hardware for sensing service consolidation and saving power. For those VMs that reside in the same hardware, frequent interdomain data transfers are invoked for data analytics, and ...
Congfeng Jiang +6 more
doaj +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
, 2022 The research study supports two SMEs, nearby located and operating in the furniture sector, whose goal is to start a collaboration with the intent of finding synergies in terms of costs reduction and development efforts related to the launch of new ...
Cimino A. +6 more
core +1 more source
Dynamics of quantum information resources in two-flavor neutrino oscillations
European Physical Journal C: Particles and FieldsThe burgeoning intersection of particle physics and quantum information science unveils significant connections, particularly in the context of neutrinos–fundamental particles that challenge our understanding of mass, mixing, and coherence at the quantum
K. El Bouzaidi +4 more
doaj +1 more source
Applying the Levels of Conceptual Interoperability Model in Support of Integratability, Interoperability, and Composability for System-of-Systems Engineering [PDF]
Journal of Systemics, Cybernetics and Informatics, 2007 The Levels of Conceptual Interoperability Model (LCIM) was developed to cope with the different layers of interoperation of modeling and simulation applications.
Andreas Tolk +2 more
doaj
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
A Model Driven Approach To Web-Based Traffic Simulation
, 2016 The Society for Modeling and Simulation International (SCS)As the world population increases the number of vehicles in the traffic increases as well, and so the traffic becomes more complex.
Çetinkaya, Deniz, Çetinkaya,D.
core
Modeling and simulation for military operations other than war [PDF]
, 2005 In the Spring Quarter of the 2005 Academic Year, the Naval Posgraduate School introduced a new course to focus on Modeling and Simulation for Military Operations Other Than War.
Blais, Curtis L.
core
A tutorial for model‐based evaluation and translation of cardiovascular safety in preclinical trials
CPT: Pharmacometrics & Systems PharmacologyAssessment of drug‐induced effects on the cardiovascular (CV) system remains a critical component of the drug discovery process enabling refinement of the therapeutic index. Predicting potential drug‐related unintended CV effects in the preclinical stage
Victoria Kulesh +6 more
doaj +1 more source