Results 51 to 60 of about 338,778 (268)

Disruptions to shared mental models from poor quality of service in collaborative virtual environments

Scientific Reports, 2021
Collaborative virtual environments are being used in various applications ranging from online games to complex team training scenarios. The key to the success of such environments is the ability of the participants to form a shared mental model of the ...
Nicholas Milef, Adam Ryason, Di Qi, Samuel O. Alfred, Cullen D. Jackson, Suvranu De   +5 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

A novel Bayesian generative approach for estimating tumor dynamics from published studies

CPT: Pharmacometrics & Systems Pharmacology
Tumor growth inhibition (TGI) modeling attempts to describe the time course changes in tumor size for patients undergoing cancer therapy. TGI models present several advantages over traditional exposure–response models that are based explicitly on ...
Arya Pourzanjani, Saurabh Modi, Jamie Connarn, Xinwen Zhang, Vijay Upreti, Chih‐Wei Lin, Khamir Mehta   +6 more
doaj   +1 more source

Approximating trigonometric functions by using exponential inequalities

Journal of Inequalities and Applications, 2019
In this paper, some exponential inequalities are derived from the inequalities containing trigonometric functions. Numerical examples show that one can achieve much tighter bounds than those of prevailing methods, which are presented by Cusa, Huygens ...
Xiao-Diao Chen, Junyi Ma, Yixin Li
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Interdomain I/O Optimization in Virtualized Sensor Networks

Sensors, 2018
In virtualized sensor networks, virtual machines (VMs) share the same hardware for sensing service consolidation and saving power. For those VMs that reside in the same hardware, frequent interdomain data transfers are invoked for data analytics, and ...
Congfeng Jiang, Tiantian Fan, Yeliang Qiu, Hongyuan Wu, Jilin Zhang, Neal N. Xiong, Jian Wan   +6 more
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

A tutorial for model‐based evaluation and translation of cardiovascular safety in preclinical trials

CPT: Pharmacometrics & Systems Pharmacology
Assessment of drug‐induced effects on the cardiovascular (CV) system remains a critical component of the drug discovery process enabling refinement of the therapeutic index. Predicting potential drug‐related unintended CV effects in the preclinical stage
Victoria Kulesh, Igor Vasyutin, Alina Volkova, Kirill Peskov, Holly Kimko, Victor Sokolov, Ravindra Alluri   +6 more
doaj   +1 more source