Results 31 to 40 of about 5,296,026 (294)
Ecohydraulics Modelling and Simulation [PDF]
Water, 2021 Ecohydraulics, the interdiscipline of ecology and hydraulics, has been rapidly developing and receiving ever-growing attention both in hydraulic research efforts and in environmentally oriented professional and lay communities in recent years [...]
openaire +2 more sources
Profiling analytical combat models using extensible modeling and simulation framework (XMSF) principles [PDF]
, 2004 The Department of Defense (Dod) is engaged in warfighting and institutional transformation for the new millenium. In parallel, the DoD Modeling & Simulation (M&S) community is working to identify and adopt transformational technologies providing direct ...
Blais, Curtis L.
core +2 more sources
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
New inequalities between the inverse hyperbolic tangent and the analogue for corresponding functions
Journal of Inequalities and Applications, 2020 In this paper, we present new inequalities which reveal further relationship for both the inverse tangent function arctan ( x ) $\arctan (x)$ and the inverse hyperbolic function arctanh ( x ) $\operatorname{arctanh}(x)$ .
Xiao-Diao Chen, Long Nie, Wangkang Huang
doaj +1 more source
Future Internet, 2023 Large language models (LLMs) excel in providing natural language responses that sound authoritative, reflect knowledge of the context area, and can present from a range of varied perspectives.
Christopher J. Lynch +5 more
doaj +1 more source
Simulation modelling for immunologists [PDF]
Nature Reviews Immunology, 2019 The immune system is inordinately complex with many interacting components determining overall outcomes. Mathematical and computational modelling provides a useful way in which the various contributions of different immunological components can be probed in an integrated manner.
Andreas Handel +2 more
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Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Infectious Diseases and TherapyIntroduction Bepirovirsen is a novel antisense oligonucleotide in development for chronic hepatitis B virus (HBV) infection therapy. Understanding the impact that clinical characteristics may have on bepirovirsen exposure is important for determining ...
Amir S. Youssef +4 more
doaj +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source