Results 31 to 40 of about 586,656 (316)
Infectious Diseases and TherapyIntroduction Bepirovirsen is a novel antisense oligonucleotide in development for chronic hepatitis B virus (HBV) infection therapy. Understanding the impact that clinical characteristics may have on bepirovirsen exposure is important for determining ...
Amir S. Youssef +4 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Modeling and simulation of call centers.
, 2006 In this review, we introduce key notions and describe the decision problems commonly encountered in call center management. Main themes are the central role of uncertainty throughout the decision hierarchy and the many operational complexities and ...
L'Ecuyer, P., Avramidis, A.N.
core +1 more source
Effect of Haptic Feedback on Pilot/Operator Performance During Flight Simulation
Applied Sciences, 2020 Flying an unmanned aerial vehicle (UAV) is a challenging task, due to the absence of direct sensory information such as a view of surroundings, sound, vibrations, and motion. It is important to provide these sensory stimulations to an operator for better
Hassam Ahmed Malik +3 more
doaj +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Extensible Modeling and Simulation Framework (XMSF) Exemplars in Analytic Combat Modeling [PDF]
, 2004 Simulation Interoperability Standards Organization (SISO) SIW Conference PaperThe Extensible Modeling and Simulation Framework (XMSF) is a composable set of standards, profiles and recommended practices for Web-based modeling & simulation (M&S) (http ...
Blais, Curtis
core
CPT: Pharmacometrics & Systems PharmacologyThe purpose of the analysis was to evaluate if 10 mg naloxone, administered intramuscularly, could reverse or prevent opioid‐induced respiratory depression (OIRD), including OIRD associated with the administration of lethal doses of high‐potency opioids.
Tae Eun Yang +7 more
doaj +1 more source
Frontiers in Applied Mathematics and StatisticsA bioeconomic delay model is developed for an algae–fish ecosystem in which the time delay τ represents the lag required for nutrients released by fish decomposition to become bioavailable.
Saida Khiyar +3 more
doaj +1 more source