Results 41 to 50 of about 327,536 (268)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Effect of Haptic Feedback on Pilot/Operator Performance During Flight Simulation

Applied Sciences, 2020
Flying an unmanned aerial vehicle (UAV) is a challenging task, due to the absence of direct sensory information such as a view of surroundings, sound, vibrations, and motion. It is important to provide these sensory stimulations to an operator for better
Hassam Ahmed Malik, Shahzad Rasool, Adnan Maqsood, Rizwan Riaz   +3 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Internet-of-Things Devices in Support of the Development of Echoic Skills among Children with Autism Spectrum Disorder

Sensors, 2021
A significant therapeutic challenge for people with disabilities is the development of verbal and echoic skills. Digital voice assistants (DVAs), such as Amazon’s Alexa, provide networked intelligence to billions of Internet-of-Things devices and have ...
Krzysztof J. Rechowicz, John B. Shull, Michelle M. Hascall, Saikou Y. Diallo, Kevin J. O’Brien   +4 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Mechanistic pharmacokinetic–pharmacodynamic modeling and simulations of naloxone auto‐injector 10 mg reversal of opioid‐induced respiratory depression

CPT: Pharmacometrics & Systems Pharmacology
The purpose of the analysis was to evaluate if 10 mg naloxone, administered intramuscularly, could reverse or prevent opioid‐induced respiratory depression (OIRD), including OIRD associated with the administration of lethal doses of high‐potency opioids.
Tae Eun Yang, Francesca Del Bene, Silvia Maria Lavezzi, Laura Iavarone, Jianping Zhang, Joseph Kim, Breanne Gjurich, Catherine Kessler   +7 more
doaj   +1 more source

Qualitative dynamics and optimal control of a delayed algae–fish bioeconomic system with nitrate recycling

Frontiers in Applied Mathematics and Statistics
A bioeconomic delay model is developed for an algae–fish ecosystem in which the time delay τ represents the lag required for nutrients released by fish decomposition to become bioavailable.
Saida Khiyar, Mohamed Hafdane, Hamza Boutayeb, Imane Elberrai   +3 more
doaj   +1 more source

Energy Aware Virtual Machine Scheduling in Data Centers

Energies, 2019
Power consumption is a primary concern in modern servers and data centers. Due to varying in workload types and intensities, different servers may have a different energy efficiency (EE) and energy proportionality (EP) even while having the same hardware
Yeliang Qiu, Congfeng Jiang, Yumei Wang, Dongyang Ou, Youhuizi Li, Jian Wan   +5 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

A Dynamic Hierarchical Evaluating Network for Real-Time Strategy Games

MATEC Web of Conferences, 2018
Researches of AI planning in Real-Time Strategy (RTS) games have been widely applied to human behavior modeling and combat simulation. State evaluation is an important research area for AI planning, which ensures the decision accuracy.
Yang Weilong, Zhang Qi, Peng Yong
doaj   +1 more source