Results 41 to 50 of about 338,778 (268)
A Dynamic Hierarchical Evaluating Network for Real-Time Strategy Games
MATEC Web of Conferences, 2018 Researches of AI planning in Real-Time Strategy (RTS) games have been widely applied to human behavior modeling and combat simulation. State evaluation is an important research area for AI planning, which ensures the decision accuracy.
Yang Weilong, Zhang Qi, Peng Yong
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Human Vaccines & Immunotherapeutics, 2023 This study assessed the cost-effectiveness of the 20-valent pneumococcal conjugate vaccine (PCV20) in Canadian infants aged
Derek Lytle +6 more
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Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
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Data‐Driven Stochastic Lie Transport Modeling of the 2D Euler Equations
Journal of Advances in Modeling Earth Systems, 2023 In this paper, we propose and assess several stochastic parametrizations for data‐driven modeling of the two‐dimensional Euler equations using coarse‐grid SPDEs.
Sagy R. Ephrati +3 more
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Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
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Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
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Simulation modeling and methodology [PDF]
ACM SIGSIM Simulation Digest, 1977 Simulation is one of the most powerful analysis tools available to those responsible for the design and/or operation of complex processes or systems. It is heavily based upon computer science, mathematics, probability theory and statistics: yet the process of simulation modeling and experimentation remains very much an intuitive art.
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Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
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Cycle Network Model of Prostaglandin H Synthase-1
Pharmaceuticals, 2020 The kinetic model of Prostaglandin H Synthase-1 (PGHS-1) was developed to investigate its complex network kinetics and non-steroidal anti-inflammatory drugs (NSAIDs) efficacy in different in vitro and in vivo conditions. To correctly describe the complex
Alexey Goltsov +3 more
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MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
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