Results 51 to 60 of about 27,508,585 (286)

Prospecting the protein design landscape

open access: yesFEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona   +4 more
wiley   +1 more source

Practitioners' perception of the impacts of virtual reality on discrete-event simulation [PDF]

open access: yes, 2005
This paper presents the results from surveying simulation practitioners from industry and academics who have used 2D or 3D software applications for Discrete-Event Simulation (DES) projects.
Akpan, J I, Brooks, R J
core   +4 more sources

Use of simulation-based learning in Japanese undergraduate nursing education: National survey results

open access: yesThe Asia Pacific Scholar, 2022
Introduction: Simulation-based learning (SBL) is a practical and efficient learning method that involves the replacement of a portion of clinical education with quality simulation experiences. It has been utilised in various countries, such as the United
Mitsumi Masuda   +2 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

open access: yesFEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise   +5 more
wiley   +1 more source

Problem of describing the function of a GPR source

open access: yesҚарағанды университетінің хабаршысы. Математика сериясы, 2020
In this paper, we consider the problem of determining the source h(t)δ(x) of electromagnetic waves from GPR data. The task of electromagnetic sensing is to find the pulse characteristic of the medium r(t) and consists in calculating the response of the ...
S.I. Kabanikhin   +4 more
doaj   +1 more source

The ubiquitin system in normal and infected germinal center B cells

open access: yesFEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis   +2 more
wiley   +1 more source

Performance improvement of single- and multi-frequency direct sampling methods in microwave imaging

open access: yesResults in Physics, 2021
Recently, it turned out that application of multiple frequency direct sampling method (DSM) does not guarantee a good result in microwave imaging. Here we propose and numerically demonstrate alternative single- and multi-frequency indicator functions of ...
Won-Kwang Park
doaj   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

open access: yesFEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

On developing efficient applications using conservative distributed simulation paradigm

open access: yes, 2001
This paper aims to present, using a set of guidelines, how to apply the conservative distributed simulation paradigm (CMB protocol) to develop efficient applications.
Spolon, Roberta   +3 more
core   +3 more sources

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

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