Results 61 to 70 of about 27,508,585 (286)
New Physically-Based Mathematical Model and Experiments for a Recently Invented Solar Pot
Applied SciencesThe studied solar pot is a recent invention, which is made for environmentally friendly cooking or heating (by utilizing solar energy) of foods and liquids.
Márton Rátkai +3 more
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Simulation as an intuition building tool for factory physics [PDF]
, 2007 In today's manufacturing environment it is absolutely critical to be competitive in order to guarantee a company's sustainability. One way to achieve this sustainability is to count on management's ability to effectively make decisions dealing with its ...
González Gómez, José Arturo +1 more
core +2 more sources
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Marine Propulsion Simulation Methods and Results
, 2015 This book describes the main steps in developing a multi-physics simulation platform, representing the dynamics of a twin screw ship in six degrees of freedom. The interaction between the propulsion system and automation effects is also considered.
Martelli, Michele
core
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Credibility assessment of simulation results [PDF]
Proceedings of the 18th conference on Winter simulation - WSC '86, 1986 The purpose of this paper is to provide some guidelines for assessing the credibility of simulation results. The life cycle of a simulation study is characterized in terms of 10 phases, 10 processes, and 13 credibility assessment stages (CASs). The credibility of simulation results is assessed by integrating ten CASs: formulated problem verification ...
openaire +2 more sources
Distance learning model and Web Simulation
, 2000 In this paper we present a WEB-based didactical simulation system that can be integrated in distance training and learning systems. It represents an innovative way of thinking to learning “by doing” models cutting down reaction time in facing and solving
ORCIUOLI, Francesco +3 more
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