Results 121 to 130 of about 15,260 (213)
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Analysis of Undergraduate Students Understanding of the Relativity of Simultaneity
, 2016 The purpose of this study was to investigate students' understanding of the relativity of simultaneity, to analyze their difficulties related to the theory of relativity, and to give some implications for effective teaching of the concept.
최우석 +3 more
core +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Reichenbach's Epsilon Definition of Simultaneity in Historical and Philosophical Perspective [PDF]
, 2001 I examine the development of Reichenbach's ideas concerning the conventionality of simultaneity in connection with his ``epsilon''-definition of simultaneity.
Rynasiewicz, Robert
core
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
TEMPORAL RELATIONS IN A WORK OF ART: IN THE EYE OF THE BEHOLDER
Вестник Кемеровского государственного университета, 2013 As any grammatical category provides variable forms for the author of a speech act, they are selected under the influence of human factor. Thus, grammar is personality dependent.
D. V. Kuznetsov
doaj
The Return of Absolute Simultaneity and its Relationship to Einstein's Relativity of Simultaneity
, 2021 In this paper we show how Einstein's relativity of simultaneity is fully consistent with anisotropic one-way speed of light. We get the same end result and observations as predicted by Einstein, but with a very diferent interpretation.
Haug, Espen Gaarder
core
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source