Results 241 to 250 of about 1,594,945 (309)

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

FEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav, Shweta Shweta, Manisha Malhotra, Vikash Maurya, Akhilesh Kumar   +4 more
wiley   +1 more source

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Comparison of Jaw Muscle Activity, Masticatory Performance, and Salivation Across Three Chewing Patterns: A Within-Subjects Experimental Study. [PDF]

Int J Dent
Paphangkorakit J, Hongsuwan S, Rattanasrithong N, Rodma B, Chaichit R.   +4 more
europepmc   +1 more source

Simultaneous immune checkpoint blockade-associated diabetes mellitus and thyrotoxicosis. [PDF]

JCEM Case Rep
Lin M, Franke M, Kudva YC.
europepmc   +1 more source

Unicompartmental and total knee arthroplasty in the same patient for the treatment of bilateral knee osteoarthritis: a systematic review of literature. [PDF]

EFORT Open Rev
Legnani C, Fadel K, D'Ambrosi R, Peretti GM, Ventura A.   +4 more
europepmc   +1 more source

Simultaneous electrochemical detection of multiple heavy metal cations using multi-walled carbon nanotubes functionalized with a ferrocenyl-based 1,4-disubstituted-1,2,3-triazole complex. [PDF]

RSC Adv
Al Khalyfeh K, Taher D, Al-As'ad R, Alasoufi AM, Al-Soeidat M, Weheabby S, Rajić V, Pašti IA, Kanoun O.   +8 more
europepmc   +1 more source

Complete Resection of Simultaneous Hepatic and Pulmonary Metastases from Colorectal Cancer in the Era of Modern Systemic and Surgical Therapies: A Systematic Review and Meta-Analysis. [PDF]

Ann Surg Oncol
Wróbel D, Rogaczewski P, Dąbrowski P, Olejek W, Borowczak J, Potocki PM.   +5 more
europepmc   +1 more source

Simultaneous Implant Placement and Guided Bone Regeneration Using Freeze-Dried Bone Allograft and Amnion-Chorion Membrane for Post-traumatic Anterior Maxillary Bone Dehiscence: A Case Report. [PDF]

Cureus
Pundir AJ, Tembhare HP, Pundhir S, Behuria PN, Sayankar S.   +4 more
europepmc   +1 more source