Results 51 to 60 of about 1,314,718 (282)
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
AxiomsIn this article, we introduce, for the first time, multivariate symmetrized and perturbed hyperbolic tangent-activated convolution-type operators in three forms.
George A. Anastassiou
doaj +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Simultaneous Approximation for Generalized Srivastava-Gupta Operators
Journal of Function Spaces, 2015 We introduce a new Stancu type generalization of Srivastava-Gupta operators to approximate integrable functions on the interval 0,∞ and estimate the rate of convergence for functions having derivatives of bounded variation.
Tuncer Acar +2 more
doaj +1 more source
Interpolation and best simultaneous approximation
Journal of Approximation Theory, 2010 The paper deals with best simultaneous approximation (b.s.a.) to \(k\) continuous functions on the interval \([a,b]\) from a finite subspace of \(C[a,b]\). The authors establish the limit of the b.s.a., which is important to provides qualitative and approximation analytic information concerning the the b.s.a.
Héctor Cuenya, Fabián E. Levis
openaire +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Quantitative Khintchine in Simultaneous Approximation
, 2022 In a ground-breaking work \cite{BY}, Beresnevich and Yang recently proved Khintchine's theorem in simultaneous Diophantine approximation for nondegenerate manifolds resolving a long-standing problem in the theory of Diophantine approximation.
Datta, Shreyasi
core
Approximation hardness of dominating set problems in bounded degree graphs [PDF]
, 2008 We study approximation hardness of the Minimum Dominating Set problem and its variants in undirected and directed graphs. Using a similar result obtained by Trevisan for Minimum Set Cover we prove the first explicit approximation lower bounds for various
Chlebikova, Janka +3 more
core +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source