Results 61 to 70 of about 51,771 (253)
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Weighted Simultaneous Approximation of the Linear Combinations of Baskakov Operators
Complexity, 2020 In this paper, the approximation property of the linear combinations of Baskakov operators is investigated by using a Jacobi weight function. Moreover, both the positive and inverse theorems for the weighted simultaneous approximation of the linear ...
Xiao-jun Tang, Xin-chang Wang, Hua Yi
doaj +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
A note on simultaneous diophantine approximation
Manuscripta Mathematica, 1981 Refining earlier investigations due to J.M.MACK [7] by a method of MORDELL it is proved that for any two irrational numbers α, β there exist infinitely many pairs of fractions p/r, q/r satisfying the inequalities $$|\alpha - \frac{p}{r}|< \frac{8}{{13}}r^{ - 3/2} ,|\beta - \frac{q}{r}|< \frac{8}{{13}}r^{ - 3/2} .$$ .
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Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Multivariate Perturbed Hyperbolic Tangent-Activated Singular Integral Approximation
MathematicsHere we study the quantitative multivariate approximation of perturbed hyperbolic tangent-activated singular integral operators to the unit operator. The engaged neural network activation function is both parametrized and deformed, and the related kernel
George A. Anastassiou
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Global Hypoellipticity and Simultaneous Approximability
Journal of Functional Analysis, 2000 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Himonas, A.Alexandrou +1 more
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Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
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Quantitative Khintchine in simultaneous approximation
Discrete and Continuous Dynamical Systems11 pages, comments welcome!
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