Results 81 to 90 of about 431,788 (272)

A note on simultaneous diophantine approximation

open access: yesManuscripta Mathematica, 1981
Refining earlier investigations due to J.M.MACK [7] by a method of MORDELL it is proved that for any two irrational numbers α, β there exist infinitely many pairs of fractions p/r, q/r satisfying the inequalities $$|\alpha - \frac{p}{r}|< \frac{8}{{13}}r^{ - 3/2} ,|\beta - \frac{q}{r}|< \frac{8}{{13}}r^{ - 3/2} .$$ .
openaire   +2 more sources

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

Multivariate Perturbed Hyperbolic Tangent-Activated Singular Integral Approximation

open access: yesMathematics
Here we study the quantitative multivariate approximation of perturbed hyperbolic tangent-activated singular integral operators to the unit operator. The engaged neural network activation function is both parametrized and deformed, and the related kernel
George A. Anastassiou
doaj   +1 more source

Juncture stress fields in multicellular shell structures. Volume I - Numerical methods of solving large matrices Final report [PDF]

open access: yes
Numerical techniques for digital computer solution of algebraic simultaneous linear equations from finite difference approximation of partial differential equations of thin elastic ...
Brogan, F. A.
core   +1 more source

Global Hypoellipticity and Simultaneous Approximability

open access: yesJournal of Functional Analysis, 2000
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Himonas, A.Alexandrou   +1 more
openaire   +2 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Small Concentration Asymptotics and Instrumental Variables Inference [PDF]

open access: yes
Poskitt and Skeels (2005) provide a new approximation to the sampling distribution of the IV estimator in a simultaneous equations model, the approximation is appropriate when the concentration parameter associated with the reduced form model is small ...
C.L. Skeels, D.S. Poskitt
core  

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

Molecular cancer prevention: Intercepting disease

open access: yesMolecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco   +2 more
wiley   +1 more source

Approximation of complex q-Beta-Baskakov-Szász-Stancu operators in compact disk

open access: yesDemonstratio Mathematica
The purpose this study is to present and investigate the qq-Beta-Baskakov-Szasz-Stancu operator. The operators are accompanied by Voronovskaja-type consequences, which include both an exact approximation order and a quantitative assessment, specifically ...
Cheregi Larisa, Mursaleen Mohammad
doaj   +1 more source

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