Results 51 to 60 of about 125,136 (305)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Model Persamaan Simultan pada Analisis Hubungan Kemiskian dan PDRB

open access: yesComTech, 2014
Simultaneous model is a model for some equation which have simultaneous relationships. It was often found in econometrics, such as the relationship between Gross Domestic Regional Product (GDRP) and poverty. GDP is a common indicator that can be used to
Rokhana Dwi Bekti   +4 more
doaj   +1 more source

The Error of Prediction for a Simultaneous Equation Model [PDF]

open access: yes
One of the most important functions of a simultaneous equation model is prediction the values of endogenous variables given the values of the predetermined variables and a lot of work has been done to estimate the accuracy of such predictions. Hooper and
Gorobets, A.
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

Predictable or Not? Forecasting Office Markets with a Simultaneous Equation Approach [PDF]

open access: yes
The main objective of this paper is to elucidate the capability of time-series regression models to capture and forecast movements in occupancy patterns, rental rates and construction activity.
Fuerst, Franz
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

The impact of agricultural production diversity on farmer household dietary diversity: a case study of Nanjing City

open access: yesFrontiers in Nutrition
Background/ObjectivesChina is one of the first developing countries to achieve poverty reduction goals, but there are still problems with unbalanced dietary structures in rural areas.
Qi Shen, Tingting Qiang, Taiyang Zhong
doaj   +1 more source

The Classical Econometric Model [PDF]

open access: yes
A compendium is presented of the various approaches that may be taken in deriving the estimators of the simultaneous-equations econometric model according to the principle of maximum likelihood.
D.S.G. Pollock
core  

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

open access: yesMolecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht   +3 more
wiley   +1 more source

Optimal significance tests in simultaneous equation models [PDF]

open access: yes
Consider testing the null hypothesis that a single structural equation has specified coefficients. The alternative hypothesis is that the relevant part of the reduced form matrix has proper rank, that is, that the equation is identified. The usual linear
Theodore W Anderson
core  

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