Results 51 to 60 of about 444,545 (304)

On-line parameter and delay estimation of continuous-time dynamic systems

International Journal of Applied Mathematics and Computer Science, 2015
The problem of on-line identification of non-stationary delay systems is considered. The dynamics of supervised industrial processes are usually modeled by ordinary differential equations.
Kozłowski Janusz, Kowalczuk Zdzisław
doaj   +1 more source

Estimation of Multilevel Simultaneous Equation Models through Genetic Algorithms

Mathematics, 2020
Problems in estimating simultaneous equation models when error terms are not intertemporally uncorrelated has motivated the introduction of a new multivariate model referred to as Multilevel Simultaneous Equation Model (MSEM).
Rocío Hernández-Sanjaime, Martín González, Jose J. López-Espín   +2 more
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Programming biological models in Python using PySB

Molecular Systems Biology, 2013
Mathematical equations are fundamental to modeling biological networks, but as networks get large and revisions frequent, it becomes difficult to manage equations directly or to combine previously developed models. Multiple simultaneous efforts to create
Carlos F Lopez, Jeremy L Muhlich, John A Bachman, Peter K Sorger   +3 more
doaj   +1 more source

Semiparametric Bayesian inference in multiple equation models [PDF]

, 2005
This paper outlines an approach to Bayesian semiparametric regression in multiple equation models which can be used to carry out inference in seemingly unrelated regressions or simultaneous equations models with nonparametric components.
Koop, Gary, Poirier, Dale J., Tobias, Justin   +2 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Program Code Generator for Cardiac Electrophysiology Simulation with Automatic PDE Boundary Condition Handling. [PDF]

PLoS ONE, 2015
Clinical and experimental studies involving human hearts can have certain limitations. Methods such as computer simulations can be an important alternative or supplemental tool. Physiological simulation at the tissue or organ level typically involves the
Florencio Rusty Punzalan, Yoshitoshi Kunieda, Akira Amano   +2 more
doaj   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Analysis of the Stability of the Model for Forecasting Mutual Volumes Russia’s Trade with BRICS Partners

Финансы: теория и практика
The paper is devoted to the construction of models for forecasting the volume of trade between Russia and the BRICS countries under sanctions. Trade between the BRICS countries is the economic foundation of their comprehensive interaction and prosperity,
L. O. Babeshko, V. A. Byvshev
doaj   +1 more source