Results 81 to 90 of about 99,043 (294)

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Simultaneous drone localisation and wind turbine model fitting during autonomous surface inspection [PDF]

, 2019
We present a method for simultaneous localisation and wind turbine model fitting for a drone performing an automated surface inspection. We use a skeletal parameteri- sation of the turbine that can be easily integrated into a non- linear least squares ...
Nikolaidis, Dimitrios, Andrew Calway, Konstantinos Karachalios, Calway, Andrew, Karachalios, Konstantinos, Oliver Moolan-Feroze, Dimitrios N. Nikolaidis, Moolan-Feroze, Oliver   +7 more
core   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Logarithmic sensitivity ratio elucidates thermal transport physics in multivariate thermoreflectance experiments

Fundamental Research
We mathematically derived a sensitivity-based method that identifies the thermal transport physics and parameters suitable for multivariate nonlinear fits in a frequency-domain thermoreflectance (FDTR) experiment.
Jing Tu, Md Azimul Haque, Derya Baran, Wee-Liat Ong   +3 more
doaj   +1 more source

Determination of Electrochemical Parameters for Electrode Reaction of La(III)/La(0) Redox Couple in a High-Temperature Molten Salt Solution

International Journal of Electrochemical Science, 2014
The electrochemical parameters on the electrodeposition of lanthanum ions in the LiCl-KCl eutectic salts were determined by linear sweep voltammetry and curve fitting program.
Tack-Jin Kim, Eun Hee Kim, Do-Hee Ahn, Kwang-Rak Kim, Seung-Woo Paek, Yongju Jung   +5 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Fitting soil particle-size distribution (PSD) models by PSD curve fitting software [PDF]

, 2019
This paper describes a particle-size distribution (PSD) curve fitting software for analyzing the soil PSD and soil physical properties. A better characterization of soil texture can be obtained by describing the soil PSD using mathematical models.
Bayat, H., Rastgou, Mostafa, Bayat, Hossein, Mansoorizadeh, Muharram, MansoorizadehM., M., Rastgou, M.   +5 more
core   +2 more sources