Results 91 to 100 of about 1,011,623 (291)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

A Revisited Half-Quadratic Approach for Simultaneous Robust Fitting of Multiple Curves [PDF]

, 2008
In this paper, we address the problem of robustly recovering several instances of a curve model from a single noisy data set with outliers. Using M-estimators revisited in a Lagrangian formalism, we derive an algorithm that we call Simultaneous Multiple Robust Fitting (SMRF), which extends the classical Iterative Reweighted Least Squares algorithm ...
Tarel, Jean Philippe, Charbonnier, Pierre, Ieng, Sio Song   +2 more
openaire   +3 more sources

Fitting interrelated datasets: metabolite diffusion and general lineshapes. [PDF]

, 2017
OBJECTIVE Simultaneous modeling of true 2-D spectroscopy data, or more generally, interrelated spectral datasets has been described previously and is useful for quantitative magnetic resonance spectroscopy applications.
Christine Sandra Bolliger, Sreenath Pruthviraj Kyathanahally, Adalid López, Víctor Javier, Döring, André, Bolliger, Christine Sandra, André Döring, Kreis, Roland, Roland Kreis, Boesch, Christoph Hans, Victor Adalid, Chris Boesch, Kyathanahally, Sreenath Pruthviraj   +11 more
core   +2 more sources

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Small area estimation of consumption per capita expenditure under simultaneous equation Rao-Yu model

MethodsX
This article proposed a simultaneous equation model for small area estimation with random area and time-varying effects called the Simultaneous Equation Rao-Yu (SERY) model. In the context of small area estimation, many socioeconomic variables are likely
Reny Ari Noviyanti, Setiawan, Agnes Tuti Rumiati   +2 more
doaj   +1 more source

Modifications of object sizes and box capacities to achieve a simultaneous fitting

Discrete Mathematics, 1977
AbstractGiven a set of k objects of positive integral sizes {si} and a set of n boxes of positive integral capacities {b1} we define a compatibility relation between each box and some subset of objects such that the condition si ⪕ b1 is necessary but not sufficient for object i to be compatible with box j.
openaire   +2 more sources

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Fortran Package for Least Squares Curve Fitting and the Solution of Simultaneous Equations [PDF]

, 1966
Fortran subroutines for least squares curve fitting and solution of simultaneous ...
Mc Carty, R. D., Hust, J. G.
core  

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Simultaneous segmentation and bias field estimation using local fitted images

Pattern Recognition, 2018
Level set methods often suffer from boundary leakage and inadequate segmentation when used to segment images with inhomogeneous intensities. To handle this issue, a novel region-based level set method was developed, in which two different local fitted images are used to construct a hybrid region intensity fitting energy functional.
Lei Wang 0163, Jianbing Zhu, Mao Sheng, Adriena Cribb, Shaocheng Zhu, Jiantao Pu   +5 more
openaire   +4 more sources