Results 11 to 20 of about 889 (197)
Sinapic Acid Regulates the LXRα–ABCG5/8 Axis in the Hepatocytes: A Potential Strategy for Cholesterol Gallstone Management [PDF]
PharmaceuticalsBackground/Objective: Gallstone disease (cholelithiasis) is a prevalent hepatobiliary disorder with limited non-surgical therapeutic options. Sinapic acid (SINAP), a phenolic compound found in various dietary sources, has demonstrated anti-inflammatory ...
Sridevi Rajendran +3 more
doaj +3 more sources
Investigaciones Geográficas, 1993 The National System for the Protection of Natural Areas (SINAP) is part of the National Institute of Ecology, former branch of the Ministry of Ecology and Urban Development (SEDUE), today Ministry of Social Development (SEDESOL). The SINAP was founded in
Carlos Melo Gallegos +1 more
doaj +3 more sources
Autologous Organoid‐T Cell Co‐Culture Platform for Modeling of Immune‐Mediated Drug‐Induced Liver Injury [PDF]
Advanced Science, Volume 12, Issue 43, November 20, 2025.A matrix‐free human liver organoid–T cell co‐culture platform enables modeling of immune‐mediated drug‐induced liver injury (iDILI). Using flucloxacillin and patient‐matched cells, this system recapitulates HLA‐B*57:01–restricted CD8⁺ T cell activation and hepatocyte damage.
Fadoua El Abdellaoui Soussi +11 more
wiley +2 more sources
Ultrasmall Au10–12 Nanoclusters: A Novel Platform for 223Ra‐Targeted Tumor α‐Therapy [PDF]
Exploration, Volume 6, Issue 2, April 2026.Encapsulating 223Ra in Au10‐12 nanoclusters and functionalizing them with RGD peptides enables targeted α‐therapy and immune microenvironment remodeling in non‐osseous tumors like triple‐negative breast cancer. This study establishes a foundational framework for novel 223Ra‐labeled α‐radiopharmaceuticals and shows strong potential for clinical ...
Yifei Jiang +11 more
wiley +2 more sources
A Comparative Study of Loan Approval Prediction Using Machine Learning Methods
Gazi Üniversitesi Fen Bilimleri DergisiLoan prediction plays an important role in the process of evaluating loan applications by financial institutions. Machine learning models can automate this process and make the lending process faster and more efficient.
Vahid Sinap
doaj +2 more sources
Gazi Üniversitesi Fen Bilimleri DergisiKonut fiyatlarının etkili bir şekilde tahmin edilmesi, ekonominin şekillenmesinde kritik bir rol oynamaktadır. Bu çalışmanın amacı, konut fiyatlarını tahminlemede en iyi performans gösteren makine öğrenmesi modelini belirlemektir.
Vahid Sinap
doaj +2 more sources
The effects of apple variety, ripening stage, and yeast strain on the volatile composition of apple cider [PDF]
Heliyon, 2019 This work examined the degree of influence of apple variety, apple ripening stage, and yeast strain on the volatile composition of apple cider. Four apple varieties grown in Estonia were selected for the study – Antei, Melba, Kulikovskoye, and Orlovski ...
Julia Rosend +3 more
doaj +2 more sources
Elevated α‐Synuclein Aggregate Levels in the Urine of Patients with Isolated REM Sleep Behavior Disorder and Parkinson's Disease [PDF]
Annals of Neurology, Volume 98, Issue 1, Page 147-151, July 2025.Parkinson's disease (PD) is a neurodegenerative disorder characterized by α‐synuclein aggregation in neurons. Recent advances suggest α‐synuclein aggregates could serve as a biomarker for PD and related synucleinopathies. This study used surface‐based fluorescence intensity distribution analysis (sFIDA) to measure α‐synuclein aggregates in urine ...
Laura Müller +9 more
wiley +2 more sources
Integrated transcriptomic and metabolomic analyses uncover the key pathways of Limonium bicolor in response to salt stress [PDF]
Plant Biotechnology Journal, Volume 23, Issue 3, Page 715-730, March 2025.Summary Salinity significantly inhibits plant growth and development. While the recretohalophyte Limonium bicolor can reduce its ion content by secreting salt, the metabolic pathways it employs to adapt to high salt stress remain unclear. This study aims to unravel this enigma through integrated transcriptomic and metabolomic analyses of L.
Zhihui Zhu +5 more
wiley +2 more sources
Lecanemab preferentially binds to smaller aggregates present at early Alzheimer's disease [PDF]
Alzheimer's &Dementia, Volume 21, Issue 4, April 2025.Abstract INTRODUCTION The monoclonal antibodies Aducanumab, Lecanemab, Gantenerumab, and Donanemab were developed for the treatment of Alzheimer's disease (AD). METHODS We used single‐molecule detection and super‐resolution imaging to characterize the binding of these antibodies to diffusible amyloid beta (Aβ) aggregates generated in‐vitro and ...
Emre Fertan +9 more
wiley +2 more sources