Results 11 to 20 of about 346 (170)

Kilikya Bölgesinin İkiz Kalesi: “Sinap”

Selçuk Üniversitesi Sosyal Bilimler Enstitüsü Dergisi, 2020
Tarih boyunca Anadolu’da şehirleri, stratejik yerleri korumak ve yol güvenliğini sağlamak için askeri yapılar inşa edilmiştir. Roma ve Bizans döneminde doğudan gelen Pers ve İslam ordularının taarruzuna karşı pek çok kale yapılmıştır.
Razan Aykaç
doaj   +3 more sources

Autologous Organoid-T Cell Co-Culture Platform for Modeling of Immune-Mediated Drug-Induced Liver Injury. [PDF]

Adv Sci (Weinh)
A matrix‐free human liver organoid–T cell co‐culture platform enables modeling of immune‐mediated drug‐induced liver injury (iDILI). Using flucloxacillin and patient‐matched cells, this system recapitulates HLA‐B*57:01–restricted CD8⁺ T cell activation and hepatocyte damage.
Soussi FEA, Brusilovsky M, Buck E, Bacon WC, Dadgar S, Fullerton A, Durban VM, Barrile R, Helmrath MA, Takebe T, Roth A, Kasendra M.   +11 more
europepmc   +2 more sources

Ultrasmall Au_10-12 Nanoclusters: A Novel Platform for ²²³Ra-Targeted Tumor α-Therapy. [PDF]

Exploration (Beijing)
Encapsulating 223Ra in Au10‐12 nanoclusters and functionalizing them with RGD peptides enables targeted α‐therapy and immune microenvironment remodeling in non‐osseous tumors like triple‐negative breast cancer. This study establishes a foundational framework for novel 223Ra‐labeled α‐radiopharmaceuticals and shows strong potential for clinical ...
Jiang Y, Yang H, Jia G, Hai W, Huang R, Wang P, Zhang M, Li D, Chen Y, Li X, Li B, Zhang C.   +11 more
europepmc   +2 more sources

Elevated α-Synuclein Aggregate Levels in the Urine of Patients with Isolated REM Sleep Behavior Disorder and Parkinson's Disease. [PDF]

Ann Neurol
Parkinson's disease (PD) is a neurodegenerative disorder characterized by α‐synuclein aggregation in neurons. Recent advances suggest α‐synuclein aggregates could serve as a biomarker for PD and related synucleinopathies. This study used surface‐based fluorescence intensity distribution analysis (sFIDA) to measure α‐synuclein aggregates in urine ...
Müller L, Özdüzenciler P, Schedlich-Teufer C, Seger A, Jergas H, Fink GR, Willbold D, Sommerauer M, Barbe MT, Tamgüney G.   +9 more
europepmc   +2 more sources

Integrated transcriptomic and metabolomic analyses uncover the key pathways of Limonium bicolor in response to salt stress. [PDF]

Plant Biotechnol J
Summary Salinity significantly inhibits plant growth and development. While the recretohalophyte Limonium bicolor can reduce its ion content by secreting salt, the metabolic pathways it employs to adapt to high salt stress remain unclear. This study aims to unravel this enigma through integrated transcriptomic and metabolomic analyses of L.
Zhu Z, Zhou Y, Liu X, Meng F, Xu C, Chen M.   +5 more
europepmc   +2 more sources

El papel de las pequeñas reservas en la conservación de mamíferos en Colombia

Caldasia, 2021
El papel de las reservas privadas generalmente se subvalora debido a su pequeño tamaño y su distri-bución discontinua. Para examinar su relevancia en la conservación de los mamíferos, con este trabajo abordamos tres objetivos: 1) identificar el patrón de
Hugo Fernando López-Arévalo, Luisa Fernanda Liévano-Latorre , Olga Lucía Montenegro Díaz   +2 more
doaj   +1 more source

Study of frost resistance and drought resistance of apple tree varieties of VNIISPK breeding on clonal rootstock 54–118 [PDF]

E3S Web of Conferences, 2021
Apple tree varieties on clonal rootstock 54–118 were studied in terms of frost resistance and drought resistance. The purpose of the research is to study the resistance to frost and drought of apple tree varieties of VNIISPK breeding on clonal rootstock ...
Galasheva Anna, Krasova Nina
doaj   +1 more source

Calcium in the “soil-plant” system of apple orchard when using nitrogen and potash fertilizers [PDF]

E3S Web of Conferences, 2021
The experiment was carried out to study the relationship between the soil calcium conditions and the content of this element in fruit and leaves of apple trees at ground fertilization with nitrogen and potassium.
Leonicheva Elena, Stolyarov Maxim, Roeva Tatyana, Leonteva Larisa   +3 more
doaj   +1 more source

Lecanemab preferentially binds to smaller aggregates present at early Alzheimer's disease. [PDF]

Alzheimers Dement
Abstract INTRODUCTION The monoclonal antibodies Aducanumab, Lecanemab, Gantenerumab, and Donanemab were developed for the treatment of Alzheimer's disease (AD). METHODS We used single‐molecule detection and super‐resolution imaging to characterize the binding of these antibodies to diffusible amyloid beta (Aβ) aggregates generated in‐vitro and ...
Fertan E, Lam JYL, Albertini G, Dewilde M, Wu Y, Akingbade OES, Böken D, English EA, De Strooper B, Klenerman D.   +9 more
europepmc   +2 more sources

Propuesta tendiente al fortalecimiento y consolidación del sistema nacional de áreas naturales protegidas (SINAP), de México

Investigaciones Geográficas, 1993
The National System for the Protection of Natural Areas (SINAP) is part of the National Institute of Ecology, former branch of the Ministry of Ecology and Urban Development (SEDUE), today Ministry of Social Development (SEDESOL). The SINAP was founded in
Carlos Melo Gallegos, José López García   +1 more
doaj   +1 more source