Results 51 to 60 of about 12,685 (261)
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This study identifies the HDAC6/GATA4/HtrA1 axis as a critical driver of cellular senescence in the inner ear. GATA4 nuclear translocation, facilitated by HDAC6 downregulation, transcriptionally activates HtrA1, promoting hair cell senescence, SASP, and audio‐vestibular dysfunction in models of Ménière's disease and age‐related audio‐vestibular ...
Na Zhang +16 more
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METHOD OF AIRBORNE SAR RADIATION CALIBRATION BASED ON POINT TARGET [PDF]
Radiation calibration of airborne SAR images is the basis for realizing the quantitative processing of airborne SAR images. Radiation calibration based on point targets is a general and convenient method.
S. Yang, Z. Xu, Z. Xu, C. Cheng
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The author gives a complete, although brief, summary of Sinc methods, with emphasis on the matrices that arise from these methods. He also presents a novel procedure, based on Sinc convolution, for solving a Poisson problem over a rectangular region.
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SETDB1 is progressively downregulated in ALD, correlating with disease severity. SETDB1 deficiency impairs LAP by disrupting Rubicon membrane localization, leading to defective lipid droplet clearance. Concurrently, loss of SETDB1 reduces nuclear LC3B, causing R‐loop accumulation and cGAS‐STING‐driven inflammation. Lipidated LC3B mediates LAP‐dependent
Yi Zhang +17 more
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Numerical indefinite integration using the sinc method [PDF]
Thesis (MSc (Mathematics))--University of Stellenbosch, 2007.In this thesis, we study the numerical approximation of indefinite integrals with algebraic or logarithmic end-point singularities.
Akinola, Richard Olatokunbo
core
Combating VEGFA‐siRNA‐Induced Metabolic Reprogramming via Glucose Utilization Deprivation
An ionizable lipid nanoparticle co‐delivers VEGFA siRNA and glucose oxidase to tumors to counteract VEGFA knockdown‐induced, glutamine‐driven metabolic compensation. Enzymatic glucose consumption reverses the adaptive pathways and restores metabolism toward baseline, thereby sensitizing tumors to therapy.
Lulu Zheng +10 more
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UCHL3 Regulates Subgenomic Flaviviral RNA Condensates to Promote Virus Propagation
ABSTRACT Flavivirus subgenomic RNAs (sfRNAs) antagonise antiviral defences, yet how sfRNAs are organized and maintained in cells remains poorly understood. Here we identify ubiquitin C‐terminal hydrolase L3 (UCHL3) as a post‐translational regulator of flavivirus sfRNA stability and function.
Oscar Trejo‐Cerro +7 more
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A numerical method based on sinc functions is developed and examined to approximate the solution of singularly perturbed Fredholm integro-differential equations. This method involves combining sinc basis functions with nonclassical weight functions. With
K. Mohammadi, A. Alipanah
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Depletion of p75NTR in Schwann Cells Driven by Inflammation Mediates Cutaneous Pain in Psoriasis
Psoriasis‐like inflammation induces proliferation and molecular remodeling of cutaneous Schwann cells, marked by reduced p75NTR and increased NGF expression. IL‐17A promotes this process, whereas Schwann cell‐specific p75NTR overexpression alleviates cutaneous pain in vivo.
Yibo Wang +9 more
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