Results 11 to 20 of about 3,551,300 (318)

Histone H2A monoubiquitination marks are targeted to specific sites by cohesin subunits in Arabidopsis

open access: yesNature Communications, 2023
Histone H2A monoubiquitination (H2Aub1) functions as a conserved posttranslational modification in eukaryotes to maintain gene expression and guarantee cellular identity.
Yu Zhang   +10 more
doaj   +1 more source

Single-Cell Multiomics

open access: yesAnnual Review of Biomedical Data Science, 2023
Single-cell RNA sequencing methods have led to improved understanding of the heterogeneity and transcriptomic states present in complex biological systems. Recently, the development of novel single-cell technologies for assaying additional modalities, specifically genomic, epigenomic, proteomic, and spatial data, allows for unprecedented insight into ...
Flynn, Emily   +2 more
openaire   +4 more sources

An atlas of dynamic peripheral blood mononuclear cell landscapes in human perioperative anaesthesia/surgery

open access: yesClinical and Translational Medicine, 2022
Background The number of patients receiving anaesthesia is increasing, but the impact of general anaesthesia on the patient's immune system remains unclear.
Yang‐Yang Wang   +10 more
doaj   +1 more source

A multilayered cross-species analysis of GRAS transcription factors uncovered their functional networks in plant adaptation to the environment

open access: yesJournal of Advanced Research, 2021
Introduction: Environmental stress is both a major force of natural selection and a prime factor affecting crop qualities and yields. The impact of the GRAS [gibberellic acid-insensitive (GAI), repressor of GA1–3 mutant (RGA), and scarecrow (SCR)] family
Moyang Liu   +6 more
doaj   +1 more source

Single-Cell Physiology [PDF]

open access: yesAnnual Review of Biophysics, 2015
Single-cell techniques have a long history of unveiling fundamental paradigms in biology. Recent improvements in the throughput, resolution, and availability of microfluidics, computational power, and genetically encoded fluorescence have led to a modern renaissance in microbial physiology.
Taheri-Araghi, Sattar   +4 more
openaire   +4 more sources

Force transmission by retrograde actin flow-induced dynamic molecular stretching of Talin

open access: yesNature Communications, 2023
Force transmission at integrin-based adhesions is important for cell migration and mechanosensing. Talin is an essential focal adhesion (FA) protein that links F-actin to integrins.
Sawako Yamashiro   +5 more
doaj   +1 more source

Single-Cell Analysis [PDF]

open access: yesCells, 2020
Cells are known to be the most fundamental building block of life [...]
Tuhin Subhra Santra, Fan-Gang Tseng
openaire   +3 more sources

A mechanism with severing near barbed ends and annealing explains structure and dynamics of dendritic actin networks

open access: yeseLife, 2022
Single molecule imaging has shown that part of actin disassembles within a few seconds after incorporation into the dendritic filament network in lamellipodia, suggestive of frequent destabilization near barbed ends.
Danielle Holz   +5 more
doaj   +1 more source

Single-Cell Nanosurgery [PDF]

open access: yes, 2013
This chapter explains the steps necessary to perform laser surgery upon single adherent mammalian cells, where individual organelles are extracted from the cells by optical tweezers and the cells are monitored post-surgery to check their viability. Single-cell laser nanosurgery is used in an increasing range of methodologies because it offers great ...
Maxwell B, Zeigler, Daniel T, Chiu
openaire   +2 more sources

The inhibition of chloride intracellular channel 1 enhances Ca2+ and reactive oxygen species signaling in A549 human lung cancer cells

open access: yesExperimental and Molecular Medicine, 2019
Cancer: chloride transport protein protects tumors A chloride channel, a membrane protein involved in chloride transport, indirectly regulates calcium signaling to protect cancer cells from free radicals and DNA damage.
Jae-Rin Lee   +5 more
doaj   +1 more source

Home - About - Disclaimer - Privacy