Results 51 to 60 of about 3,861,359 (307)

Real‐World Pediatric Blinatumomab Administration: Access to Outpatient Care Delivery and Impact of a Hospital‐Dispensed Model

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Blinatumomab has been shown to be highly effective for patients with pediatric B‐ALL and has recently become standard of care therapy. Due to its past use in the clinical trial setting, there is limited information available about real‐world administration.
Katelyn Oranges, Kelly A. Duffy, Sara McDonough, Evelyn Kurpiewski, R. Jennifer Randall, Allison Barz Leahy, Haley M. Newman, Joyce P. Lee, Stephen P. Hunger, Anne F. Reilly, David T. Teachey, Susan R. Rheingold, Daniel J. Zheng   +12 more
wiley   +1 more source

Identification and characterization of planarian multinucleated cells in Schmidtea mediterranea using imaging flow cytometry

Frontiers in Cell and Developmental Biology
Cellular polyploidy plays critical roles in both pathological and physiological processes. While extensively studied in organisms like Drosophila and zebrafish, and mammalian tissues such as the liver, kidney and heart, the existence of multinucleated ...
Annasha Dutta, Anna Samelak-Czajka, Magdalena Trybus, Marcin Osuch, Anastasiia Zaremba, Paulina Jackowiak   +5 more
doaj   +1 more source

Folate-based single cell screening using surface enhanced Raman microimaging [PDF]

, 2016
Recent progress in nanotechnology and its application to biomedical settings have generated great advantages in dealing with early cancer diagnosis.
Bordi, Federico, Costantini, Francesca, Domenici, F., Fasolato, Claudia, Giantulli, Sabrina, Luongo, F., Mazzarda, Flavia, Mura, Francesco, Postorino, Paolo, Ripanti, Francesca, Silvestri, Ida, Toumia, Y.   +11 more
core   +1 more source

Clinical Insights Into Hypercalcemia of Malignancy in Childhood

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Hypercalcemia of malignancy (HCM) is a rare but life‐threatening metabolic emergency in children that occurs in less than 1% of pediatric cancer cases, with a reported incidence ranging from 0.4% to 1.0% across different studies. While it is observed in 10%–20% of adult malignancies, pediatric HCM remains relatively uncommon.
Hüseyin Anıl Korkmaz
wiley   +1 more source

Data Exploration, Quality Control and Testing in Single-Cell qPCR-Based Gene Expression Experiments [PDF]

, 2012
Cell populations are never truly homogeneous; individual cells exist in biochemical states that define functional differences between them. New technology based on microfluidic arrays combined with multiplexed quantitative polymerase chain reactions ...
Chattopadyay, Pratip K., Dominguez, Maria, Finak, Greg, Gottardo, Raphael, Lamoreaux, Laurie, Ma, Steven S., McDavid, Andrew, Roederer, Mario   +7 more
core  

Combined aptamer and transcriptome sequencing of single cells. [PDF]

, 2018
The transcriptome and proteome encode distinct information that is important for characterizing heterogeneous biological systems. We demonstrate a method to simultaneously characterize the transcriptomes and proteomes of single cells at high throughput ...
Abate, Adam R, Delley, Cyrille L, Liu, Leqian, Sarhan, Maen F   +3 more
core   +2 more sources

Survival Outcomes and Complications Among Canadian Children With Retinoblastoma: A Population‐Based Report From CYP‐C

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Retinoblastoma (RB) is the most common pediatric ocular cancer, yet population‐based data on survival and risk factors remain limited. This study aimed to describe survival in a large national RB cohort and identify predictors of death and complications.
Samuel Sassine, Ofélie Trudeau‐Ferrin, Caroline Laverdière, Patrick Hamel, Rosanne Superstein, Bénédicte Koukoui, Carole Provost, Paul C. Nathan, Vijay Ramaswamy, Furqan Shaikh, Brenda Gallie, Ashwin Mallipatna, Stephanie Kletke, Helen Dimaras, Hallie Coltin   +14 more
wiley   +1 more source

Powerful and accurate detection of temporal gene expression patterns from multi-sample multi-stage single-cell transcriptomics data with TDEseq

Genome Biology
We present a non-parametric statistical method called TDEseq that takes full advantage of smoothing splines basis functions to account for the dependence of multiple time points in scRNA-seq studies, and uses hierarchical structure linear additive mixed ...
Yue Fan, Lei Li, Shiquan Sun
doaj   +1 more source

Tumor microenvironment-responsive DNA-based nanomedicine triggers innate sensing for enhanced immunotherapy

Journal of Nanobiotechnology, 2023
Lack of proper innate sensing inside the tumor microenvironment could reduce both innate and adaptive immunity, which remains a critical cause of immunotherapy failure in various tumor treatments.
Jinyang Li, Xiaoyu Han, Shanshan Gao, Yumeng Yan, Xiaoguang Li, Hui Wang   +5 more
doaj   +1 more source

Single cell mechanics: stress stiffening and kinematic hardening

, 2007
Cell mechanical properties are fundamental to the organism but remain poorly understood. We report a comprehensive phenomenological framework for the nonlinear rheology of single fibroblast cells: a superposition of elastic stiffening and viscoplastic ...
A. Mogilner, Albrecht Ott, D. Bray, N. Wang, O. Thoumine, Pablo Fernández, S. Nemat-Nasser, T. Wakatsuki, U. F. Kocks, W. Prager, Y. C. Fung   +10 more
core   +1 more source