Results 191 to 200 of about 5,714,705 (321)

ShortCake: an integrated platform for efficient and reproducible single-cell analysis. [PDF]

Bioinformatics
Nakato R, Nagai LAE.
europepmc   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Single-cell analysis of B cell dysregulation in pediatric sepsis stratified by disease severity. [PDF]

Sci Rep
Alhamdan F, Gianoli S, Yuki K, Koutsogiannaki S.   +3 more
europepmc   +1 more source

Single-cell RNA-seq analysis profiling characterizes differences in cell composition and physiology between normal tissue, treatment naive, and cisplatin-treated ovarian cancer [PDF]

Fang Guo, Zhijun Yang, Jalid Sehouli, Andreas M. Kaufmann   +3 more
openalex   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Immunoregulatory Roles of Tumor-Originated Pericytes Identified by Single-Cell Analysis in Glioblastoma. [PDF]

Adv Sci (Weinh)
Chu C, Li F, Zhang Z, Zhu Q, Yan H, Cheng M, Wang H, Cheng L, Zhang Z, Yu X, Man J, Wang W, Li D, Bian XW, Wu HB, Zhang A, Zhou W.   +16 more
europepmc   +1 more source

Multi-Omics Single-Cell Analysis Reveals Key Regulators of HIV-1 Persistence and Aberrant Host Immune Responses in Early Infection [PDF]

Dayeon Lee, Sin Young Choi, So-I Shin, Hyunsu An, Byeong‐Sun Choi, Jihwan Park   +5 more
openalex   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Three-dimensional forward-scattering imaging flow cytometry system for single-cell analysis. [PDF]

APL Photonics
Zhou M, Zhao J, Chen X, Zhang Z, Lai Z, Zhou Z, de la Zerda A, Lo YH.   +7 more
europepmc   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source