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Mendelian randomization and single-cell analysis reveal novel genetic risk factors and cellular heterogeneity in glioblastoma. [PDF]
Li J, Xu J, Ding L, Chen J.
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Single-Cell Transcriptional Analysis
Annual Review of Analytical Chemistry, 2017Despite being a relatively recent technological development, single-cell transcriptional analysis through high-throughput sequencing has already been used in hundreds of fruitful studies to make exciting new biological discoveries that would otherwise be challenging or even impossible.
Wu, Angela Ruohao +3 more
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Integrative single-cell analysis
Nature Reviews Genetics, 2019The recent maturation of single-cell RNA sequencing (scRNA-seq) technologies has coincided with transformative new methods to profile genetic, epigenetic, spatial, proteomic and lineage information in individual cells. This provides unique opportunities, alongside computational challenges, for integrative methods that can jointly learn across multiple ...
Tim Stuart, Rahul Satija
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Microfluidics for single cell analysis
2022Cells have several internal molecules that are present in low amounts and any fluctuation in its number drives a change in cell behavior. These molecules present inside the cells are continuously fluctuating, thus producing noises in the intrinsic environment and thereby directly affecting the cellular behavior. Single-cell analysis using microfluidics
Rupesh, Maurya +5 more
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Analytical and Bioanalytical Chemistry, 2006
Why is it important to study single cells? Scientists have long pondered the purpose of increasingly smaller biological entities within various organisms, with the cell acknowledged to be one of the fundamental building blocks of life. Furthermore, individual cells have discrete molecular, metabolic, and proteomic identities. Analogous to the pieces of
Jonathan V. Sweedler, Edgar A. Arriaga
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Why is it important to study single cells? Scientists have long pondered the purpose of increasingly smaller biological entities within various organisms, with the cell acknowledged to be one of the fundamental building blocks of life. Furthermore, individual cells have discrete molecular, metabolic, and proteomic identities. Analogous to the pieces of
Jonathan V. Sweedler, Edgar A. Arriaga
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Microfluidic Single‐Cell Omics Analysis
Small, 2019AbstractThe commonly existing cellular heterogeneity plays a critical role in biological processes such as embryonic development, cell differentiation, and disease progress. Single‐cell omics‐based heterogeneous studies have great significance for identifying different cell populations, discovering new cell types, revealing informative cell features ...
Xing Xu +8 more
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