Results 291 to 300 of about 5,522,894 (323)

Housekeeping gene dysregulation in psoriasis: integrative multi-cohort and single-cell analysis reveals keratinocyte-centric molecular mechanisms and diagnostic biomarkers. [PDF]

Front Immunol
Tang H, Wang J, Zhang S, Feng G, Cheng X, Meng X, Chen R, Wang J, Jiang Y, Zhang R, Lv W.   +10 more
europepmc   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

A pan-cancer single-cell analysis reveals the effect of PD-1 blockades on tumor angiogenesis by inhibiting the endothelial CXCL12-CXCR4 axis. [PDF]

Cancer Immunol Immunother
Muhetarijiang M, Zhu P, Zhang H, Sun X, Wu Y, Xu Q, Justin R, Li C, Zhou D, Zhang B, Liu J, Hu X, Chen T.   +12 more
europepmc   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Single-Cell Analysis Reveals Fibroblast-Derived Migrasomes as CXCL12 Carriers Promoting Skin Wound Repair. [PDF]

J Extracell Vesicles
Zhou H, Zhang Z, Liu Z, Sa G, Jiang M, Zou Z, Shi Y, Zheng L, Yang X, Sa G.   +9 more
europepmc   +1 more source

Panoramic analysis of the biological function and clinical value of SLC38A2 in human cancers: a study based on pan-cancer and single-cell analysis. [PDF]

Front Genet
Liao M, Rao Y, Li M, Guo J, Guo K, Li K, Zheng R, Liu Y, Wang Q, Wang M, Chen D, Zhang M, Wang Y, Zhao Y, Li S.   +14 more
europepmc   +1 more source

Spatiotemporal single-cell analysis elucidates the cellular and molecular dynamics of human cornea aging. [PDF]

Genome Med
Jiang D, Li K, Sun Y, Zhang Z, Xie S, Yu X, Wang R, Feng Y, Zheng Q, Wen Y, Reinach PS, Du Y, Zhou M, Chen W.   +13 more
europepmc   +1 more source

Protocol for rapid 5-plex 3D imaging and single-cell analysis of immune responses in whole murine lymph nodes. [PDF]

STAR Protoc
Boulat V, Ciccarelli A, Hung MS, Zhang L, Grigoriadis A, Calado DP.   +5 more
europepmc   +1 more source

Monitoring Immune Responses to Vaccination: A Focus on Single-Cell Analysis and Associated Challenges. [PDF]

Vaccines (Basel)
Montgomery L, Larbi A.
europepmc   +1 more source