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Cnidarian Cell Type Diversity and Regulation Revealed by Whole-Organism Single-Cell RNA-Seq
Cell, 2018 International audienceThe emergence and diversification of cell types is a leading factor in animal evolution. So far, systematic characterization of the gene regulatory programs associated with cell type specificity was limited to few cell types and few
Arnau Sebé-Pedrós +2 more
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Analytical and Bioanalytical Chemistry, 2006
Why is it important to study single cells? Scientists have long pondered the purpose of increasingly smaller biological entities within various organisms, with the cell acknowledged to be one of the fundamental building blocks of life. Furthermore, individual cells have discrete molecular, metabolic, and proteomic identities. Analogous to the pieces of
Jonathan V. Sweedler, Edgar A. Arriaga
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Why is it important to study single cells? Scientists have long pondered the purpose of increasingly smaller biological entities within various organisms, with the cell acknowledged to be one of the fundamental building blocks of life. Furthermore, individual cells have discrete molecular, metabolic, and proteomic identities. Analogous to the pieces of
Jonathan V. Sweedler, Edgar A. Arriaga
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Single Cell Analysis of Proteoforms
Journal of Proteome ResearchWe introduce single cell Proteoform imaging Mass Spectrometry (scPiMS), which realizes the benefit of direct solvent extraction and MS detection of intact proteins from single cells dropcast onto glass slides. Sampling and detection of whole proteoforms by individual ion mass spectrometry enable a scalable approach to single cell proteomics.
Pei Su +12 more
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Microfluidic Device for Single-Cell Analysis
Analytical Chemistry, 2003We have developed a novel microfluidic device constructed from poly(dimethylsiloxane) using multilayer soft lithography technology for the analysis of single cells. The microfluidic network enables the passive and gentle separation of a single cell from the bulk cell suspension, and integrated valves and pumps enable the precise delivery of nanoliter ...
Aaron R, Wheeler +8 more
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Microtechnologies and nanotechnologies for single-cell analysis
Current Opinion in Biotechnology, 2004Many efforts are currently underway to try and mimic the properties of single cells with the aim of designing chips that are as efficient as cells. However, cells are nature's nanotechnology engineering at the scale of atoms and molecules, and it might be better to envision a microchip that utilizes a single cell as an experimentation platform. A novel,
Andersson, Helene, van den Berg, Albert
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Microfluidic Single‐Cell Omics Analysis
Small, 2019AbstractThe commonly existing cellular heterogeneity plays a critical role in biological processes such as embryonic development, cell differentiation, and disease progress. Single‐cell omics‐based heterogeneous studies have great significance for identifying different cell populations, discovering new cell types, revealing informative cell features ...
Xing Xu +8 more
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The Single-Cell Lab or How to Perform Single-Cell Molecular Analysis
2015The increasing interest towards cellular heterogeneity within cell populations has pushed the development of new protocols to isolate and analyze single cells. PCR-based amplification techniques are widely used in this field. However, setting up an experiment and analyzing the results can sometimes be challenging.
Roland, Kirchner +1 more
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Analysis of gene expression in single cells
Current Opinion in Biotechnology, 1999A cell's structural and functional characteristics are dependent on the specific complement of genes it expresses. The ability to study and compare gene usage at the cellular level will therefore provide valuable insights into cell physiology. Such analyses are complicated by problems associated with sample collection, sample size and the limited ...
T C, Freeman, K, Lee, P J, Richardson
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Single-cell immune repertoire analysis
Nature MethodsSingle-cell T cell and B cell antigen receptor-sequencing data analysis can potentially perform in-depth assessments of adaptive immune cells that inform on understanding immune cell development to tracking clonal expansion in disease and therapy. However, it has been extremely challenging to analyze and interpret T cells and B cells and their adaptive
Sergio E. Irac +3 more
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Environmental analysis of single cells
Analytical and Bioanalytical Chemistry, 2006Qiang, Zhao, X Chris, Le
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