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Nippon Shokuhin Kagaku Kogaku Kaishi, 2021 Cells are the most fundamental building block of all living organisms. The investigation of any type of disease mechanism and its progression still remains challenging due to cellular heterogeneity characteristics and physiological state of cells in a ...
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Microfluidics for single cell analysis
2022Cells have several internal molecules that are present in low amounts and any fluctuation in its number drives a change in cell behavior. These molecules present inside the cells are continuously fluctuating, thus producing noises in the intrinsic environment and thereby directly affecting the cellular behavior. Single-cell analysis using microfluidics
Rupesh, Maurya +5 more
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Microfluidics for single cell analysis
Current Opinion in Biotechnology, 2012Substantial evidence shows that the heterogeneity of individual cells within a genetically identical population can be critical to their chance of survival. Methods that use average responses from a population often mask the difference from individual cells.
Huabing, Yin, Damian, Marshall
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Integrative single-cell analysis
Nature Reviews Genetics, 2019The recent maturation of single-cell RNA sequencing (scRNA-seq) technologies has coincided with transformative new methods to profile genetic, epigenetic, spatial, proteomic and lineage information in individual cells. This provides unique opportunities, alongside computational challenges, for integrative methods that can jointly learn across multiple ...
Tim Stuart, Rahul Satija
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Single-Cell Transcriptional Analysis
Annual Review of Analytical Chemistry, 2017Despite being a relatively recent technological development, single-cell transcriptional analysis through high-throughput sequencing has already been used in hundreds of fruitful studies to make exciting new biological discoveries that would otherwise be challenging or even impossible.
Wu, Angela Ruohao +3 more
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Single-cell analysis at the threshold
Nature Biotechnology, 2016A discussion of some of the challenges and promise of single-cell technology. ; © 2016 Nature Publishing Group. Published 08 November 2016.
Chen, Xi +7 more
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Chemical Analysis of Single Cells
Annual Review of Analytical Chemistry, 2008Chemical analysis of single cells requires methods for quickly and quantitatively detecting a diverse array of analytes from extremely small volumes (femtoliters to nanoliters) with very high sensitivity and selectivity. Microelectrophoretic separations, using both traditional capillary electrophoresis and emerging microfluidic methods, are well ...
Laura M, Borland +3 more
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Single cell analysis at the nanoscale
Chem. Soc. Rev., 2012The fundamental life processes such as signal transduction, intracellular trafficking, protein degradation, and DNA repair often occur in nanometric subcellular compartments. It is essential to conduct single cell analysis specifically at the nanoscale to fully understand the critical cellular processes while providing important medical applications ...
Zheng, Xin Ting, Li, Chang Ming
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Single-cell analysis targeting the proteome
Nature Reviews Chemistry, 2020The existence of cellular heterogeneity and its central relevance to biological phenomena provides a strong rationale for a need for analytical methods that enable analysis at the single-cell level. Analysis of the genome and transcriptome is possible at the single-cell level, but the comprehensive interrogation of the proteome with this level of ...
Mahmoud Labib, Shana O. Kelley
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Single-Cell Transcriptome Analysis of Treg
2022Regulatory T-cells (Treg) are considerably heterogeneous. Thymically derived Treg (tTreg) are those, which differentiate in the thymus, while peripherally derived Treg (pTreg) differentiate from peripheral mature CD4+ T-cells. These two populations are often identified using markers such as neuropilin-1 and Helios (for tTreg) and ROR-γt (for pTreg) in ...
Benjy Jek Yang, Tan +2 more
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