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Integrative single-cell analysis
Nature Reviews Genetics, 2019The recent maturation of single-cell RNA sequencing (scRNA-seq) technologies has coincided with transformative new methods to profile genetic, epigenetic, spatial, proteomic and lineage information in individual cells. This provides unique opportunities, alongside computational challenges, for integrative methods that can jointly learn across multiple ...
Tim Stuart, Rahul Satija
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Single-Cell Transcriptional Analysis
Annual Review of Analytical Chemistry, 2017Despite being a relatively recent technological development, single-cell transcriptional analysis through high-throughput sequencing has already been used in hundreds of fruitful studies to make exciting new biological discoveries that would otherwise be challenging or even impossible.
Wu, Angela Ruohao +3 more
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Microfluidics for single cell analysis
2022Cells have several internal molecules that are present in low amounts and any fluctuation in its number drives a change in cell behavior. These molecules present inside the cells are continuously fluctuating, thus producing noises in the intrinsic environment and thereby directly affecting the cellular behavior. Single-cell analysis using microfluidics
Rupesh, Maurya +5 more
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Analytical and Bioanalytical Chemistry, 2006
Why is it important to study single cells? Scientists have long pondered the purpose of increasingly smaller biological entities within various organisms, with the cell acknowledged to be one of the fundamental building blocks of life. Furthermore, individual cells have discrete molecular, metabolic, and proteomic identities. Analogous to the pieces of
Jonathan V. Sweedler, Edgar A. Arriaga
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Why is it important to study single cells? Scientists have long pondered the purpose of increasingly smaller biological entities within various organisms, with the cell acknowledged to be one of the fundamental building blocks of life. Furthermore, individual cells have discrete molecular, metabolic, and proteomic identities. Analogous to the pieces of
Jonathan V. Sweedler, Edgar A. Arriaga
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Microfluidic Single‐Cell Omics Analysis
Small, 2019AbstractThe commonly existing cellular heterogeneity plays a critical role in biological processes such as embryonic development, cell differentiation, and disease progress. Single‐cell omics‐based heterogeneous studies have great significance for identifying different cell populations, discovering new cell types, revealing informative cell features ...
Xing Xu +8 more
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Microfluidics for single cell analysis
Current Opinion in Biotechnology, 2012Substantial evidence shows that the heterogeneity of individual cells within a genetically identical population can be critical to their chance of survival. Methods that use average responses from a population often mask the difference from individual cells.
Huabing, Yin, Damian, Marshall
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High-Parameter Single-Cell Analysis
Annual Review of Analytical Chemistry, 2019Thousands of transcripts and proteins confer function and discriminate cell types in the body. Using high-parameter technologies, we can now measure many of these markers at once, and multiple platforms are now capable of analysis on a cell-by-cell basis.
Pratip K, Chattopadhyay +4 more
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Chemical Analysis of Single Cells
Annual Review of Analytical Chemistry, 2008Chemical analysis of single cells requires methods for quickly and quantitatively detecting a diverse array of analytes from extremely small volumes (femtoliters to nanoliters) with very high sensitivity and selectivity. Microelectrophoretic separations, using both traditional capillary electrophoresis and emerging microfluidic methods, are well ...
Laura M, Borland +3 more
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Parallel single‐cell analysis microfluidic platform
ELECTROPHORESIS, 2011AbstractWe report a PDMS microfluidic platform for parallel single‐cell analysis (PaSCAl) as a powerful tool to decipher the heterogeneity found in cell populations. Cells are trapped individually in dedicated pockets, and thereafter, a number of invasive or non‐invasive analysis schemes are performed. First, we report single‐cell trapping in a fast (2–
van den Brink, Floris T.G. +5 more
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