Results 91 to 100 of about 1,198,587 (324)
bioRxiv, 2020 Autonomous regulation of the intestine requires the combined activity of functionally distinct neurons of the enteric nervous system (ENS). However, the variety of enteric neuron types and how they emerge during development remain largely unknown.
Khomgrit Morarach +7 more
semanticscholar +1 more source
Genome Biology, 2022 Background Cell-cell interactions are important for information exchange between different cells, which are the fundamental basis of many biological processes.
Zhaoyang Liu, Dongqing Sun, Chenfei Wang
semanticscholar +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Mesothelioma cell heterogeneity identified by single cell RNA sequencing
Scientific ReportsMesothelioma cell heterogeneity encompasses diverse morphological and molecular characteristics observed within tumors, significantly impacting disease progression, treatment outcomes, and the development of targeted therapies.
Licun Wu +4 more
doaj +1 more source
Automatic cell type identification methods for single-cell RNA sequencing
Computational and Structural Biotechnology Journal, 2021 Single-cell RNA sequencing (scRNA-seq) has become a powerful tool for scientists of many research disciplines due to its ability to elucidate the heterogeneous and complex cell-type compositions of different tissues and cell populations. Traditional cell-
Bingbing Xie +3 more
doaj +1 more source
A comparison of automatic cell identification methods for single-cell RNA sequencing data
Genome Biology, 2019 Single-cell transcriptomics is rapidly advancing our understanding of the cellular composition of complex tissues and organisms. A major limitation in most analysis pipelines is the reliance on manual annotations to determine cell identities, which are ...
T. Abdelaal +6 more
semanticscholar +1 more source
bioRxiv, 2022 The role of therapy in shaping the tumor microenvironment in pancreatic ductal adenocarcinoma (PDAC) remains to be explored. Here, the authors perform single-cell RNA sequencing in PDAC samples before and after chemotherapy and suggest that chemotherapy ...
G. Werba +20 more
semanticscholar +1 more source
Virtual Environment for Next Generation Sequencing Analysis [PDF]
, 2012 Next Generation Sequencing technology, on the one hand, allows a more accurate analysis, and, on the other hand, increases the amount of data to process.
Abate, Francesco +4 more
core
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Single-cell RNA sequencing reveals functional heterogeneity of glioma-associated brain macrophages
Nature Communications, 2021 Microglia are resident myeloid cells in the central nervous system (CNS) that control homeostasis and protect CNS from damage and infections. Microglia and peripheral myeloid cells accumulate and adapt tumor supporting roles in human glioblastomas that ...
Natalia Ochocka +7 more
semanticscholar +1 more source