Results 101 to 110 of about 1,214,396 (338)
Single-cell RNA sequencing reveals functional heterogeneity of glioma-associated brain macrophages
Nature Communications, 2021 Microglia are resident myeloid cells in the central nervous system (CNS) that control homeostasis and protect CNS from damage and infections. Microglia and peripheral myeloid cells accumulate and adapt tumor supporting roles in human glioblastomas that ...
Natalia Ochocka +7 more
semanticscholar +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Mesothelioma cell heterogeneity identified by single cell RNA sequencing
Scientific ReportsMesothelioma cell heterogeneity encompasses diverse morphological and molecular characteristics observed within tumors, significantly impacting disease progression, treatment outcomes, and the development of targeted therapies.
Licun Wu +4 more
doaj +1 more source
Automatic cell type identification methods for single-cell RNA sequencing
Computational and Structural Biotechnology Journal, 2021 Single-cell RNA sequencing (scRNA-seq) has become a powerful tool for scientists of many research disciplines due to its ability to elucidate the heterogeneous and complex cell-type compositions of different tissues and cell populations. Traditional cell-
Bingbing Xie +3 more
doaj +1 more source
A practical guide to single-cell RNA-sequencing for biomedical research and clinical applications
Genome Medicine, 2017 RNA sequencing (RNA-seq) is a genomic approach for the detection and quantitative analysis of messenger RNA molecules in a biological sample and is useful for studying cellular responses.
A. Haque +3 more
semanticscholar +1 more source
scCATCH: Automatic Annotation on Cell Types of Clusters from Single-Cell RNA Sequencing Data
iScience, 2020 Summary Recent advancements in single-cell RNA sequencing (scRNA-seq) have facilitated the classification of thousands of cells through transcriptome profiling, wherein accurate cell type identification is critical for mechanistic studies.
Xin Shao +5 more
semanticscholar +1 more source
Characterization of the COPD alveolar niche using single-cell RNA sequencing
Nature Communications, 2022 Chronic obstructive pulmonary disease (COPD) is a leading cause of death worldwide, however our understanding of cell specific mechanisms underlying COPD pathobiology remains incomplete.
M. Sauler +25 more
semanticscholar +1 more source
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
Combined aptamer and transcriptome sequencing of single cells. [PDF]
, 2018 The transcriptome and proteome encode distinct information that is important for characterizing heterogeneous biological systems. We demonstrate a method to simultaneously characterize the transcriptomes and proteomes of single cells at high throughput ...
Abate, Adam R +3 more
core +2 more sources
bioRxiv, 2020 Autonomous regulation of the intestine requires the combined activity of functionally distinct neurons of the enteric nervous system (ENS). However, the variety of enteric neuron types and how they emerge during development remain largely unknown.
Khomgrit Morarach +7 more
semanticscholar +1 more source