Results 111 to 120 of about 1,214,396 (338)

Evaluation of cell-cell interaction methods by integrating single-cell RNA sequencing data with spatial information

Genome Biology, 2022
Background Cell-cell interactions are important for information exchange between different cells, which are the fundamental basis of many biological processes.
Zhaoyang Liu, Dongqing Sun, Chenfei Wang
semanticscholar   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Single cell RNA sequencing: modern approaches and achievements

RUDN Journal of Medicine
Relevance. Single-cell RNA sequencing (scRNA-seq) is a modern approach to studying the diversity and heterogeneity of RNA transcripts in individual cells, as well as to identifying the composition of different cell types and functions in organisms ...
Artem E. Gusev, Petr V. Chernov, Nikolai A. Dmitriev, Ilya A. Kofiadi   +3 more
doaj   +1 more source

Single-cell transcriptome sequencing: recent advances and remaining challenges [version 1; referees: 2 approved]

F1000Research, 2016
Single-cell RNA-sequencing methods are now robust and economically practical and are becoming a powerful tool for high-throughput, high-resolution transcriptomic analysis of cell states and dynamics.
Serena Liu, Cole Trapnell
doaj   +1 more source

Virtual Environment for Next Generation Sequencing Analysis [PDF]

, 2012
Next Generation Sequencing technology, on the one hand, allows a more accurate analysis, and, on the other hand, increases the amount of data to process.
Abate, Francesco, Acquaviva, Andrea, Mossucca, L., Provenzano, R., Terzo, Olivier   +4 more
core  

Virtual in situs: Sequencing mRNA from cryo-sliced Drosophila embryos to determine genome-wide spatial patterns of gene expression [PDF]

, 2013
Complex spatial and temporal patterns of gene expression underlie embryo differentiation, yet methods do not yet exist for the efficient genome-wide determination of spatial expression patterns during development.
Combs, Peter A., Eisen, Michael B.
core   +4 more sources

Conserved properties of dentate gyrus neurogenesis across postnatal development revealed by single-cell RNA sequencing

Nature Neuroscience, 2018
The dentate gyrus of the hippocampus is a brain region in which neurogenesis persists into adulthood; however, the relationship between developmental and adult dentate gyrus neurogenesis has not been examined in detail.
Hannah Hochgerner, Amit Zeisel, P. Lönnerberg, S. Linnarsson   +3 more
semanticscholar   +1 more source

Single-cell RNA sequencing highlights the role of inflammatory cancer-associated fibroblasts in bladder urothelial carcinoma

Nature Communications, 2020
Although substantial progress has been made in cancer biology and treatment, clinical outcomes of bladder carcinoma (BC) patients are still not satisfactory. The tumor microenvironment (TME) is a potential target. Here, by single-cell RNA sequencing on 8
Zhaohui Chen, Lijie Zhou, Lilong Liu, Yaxin Hou, M. Xiong, Yu Yang, Junyi Hu, Ke Chen   +7 more
semanticscholar   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Identification of CNS Injury-Related microRNAs as Novel Toll-Like Receptor 7/8 Signaling Activators by Small RNA Sequencing [PDF]

, 2020
Toll-like receptors (TLRs) belong to pattern recognition receptors, which respond to danger signals such as pathogen-associated molecular patterns or damage-associated molecular patterns.
Buonfiglioli, Alice, Dembny, Paul, Krüger, Christina, Lehnardt, Seija, Prinz, Marco, Staszewski, Ori, Wallach, Thomas, Wetzel, Max   +7 more
core   +1 more source