Results 11 to 20 of about 706,319 (217)

Single-Cell RNA Sequencing in Parkinson’s Disease

Biomedicines, 2021
Single-cell and single-nucleus RNA sequencing (sc/snRNA-seq) technologies have enhanced the understanding of the molecular pathogenesis of neurodegenerative disorders, including Parkinson’s disease (PD).
Shi-Xun Ma, Su Bin Lim
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scDA: Single cell discriminant analysis for single-cell RNA sequencing data

Computational and Structural Biotechnology Journal, 2021
Single-cell RNA-sequencing (scRNA-seq) techniques provide unprecedented opportunities to investigate phenotypic and molecular heterogeneity in complex biological systems.
Qianqian Shi, Xinxing Li, Qirui Peng, Chuanchao Zhang, Luonan Chen   +4 more
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Single-cell RNA sequencing in orthopedic research

Bone Research, 2023
Although previous RNA sequencing methods have been widely used in orthopedic research and have provided ideas for therapeutic strategies, the specific mechanisms of some orthopedic disorders, including osteoarthritis, lumbar disc herniation, rheumatoid ...
Tao Wang, Ling Wang, Liping Zhang, Yubin Long, Yingze Zhang, Zhiyong Hou   +5 more
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Microglia Heterogeneity in Alzheimer’s Disease: Insights From Single-Cell Technologies

Frontiers in Synaptic Neuroscience, 2021
Microglia are resident immune cells in the central nervous system and play critical roles in brain immunity, development, and homeostasis. The pathology of Alzheimer’s disease (AD) triggers activation of microglia.
Hansen Wang
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Single Cell RNA Sequencing of Rare Immune Cell Populations

Frontiers in Immunology, 2018
Single-cell RNA sequencing (scRNA-Seq) is transforming our ability to characterize cells, particularly rare cells that are often overlooked in bulk population analytical approaches.
Akira Nguyen, Akira Nguyen, Weng Hua Khoo, Weng Hua Khoo, Imogen Moran, Imogen Moran, Peter I. Croucher, Peter I. Croucher, Tri Giang Phan, Tri Giang Phan   +9 more
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The Application of Single-Cell RNA Sequencing in Vaccinology

Journal of Immunology Research, 2020
Single-cell RNA sequencing allows highly detailed profiling of cellular immune responses from limited-volume samples, advancing prospects of a new era of systems immunology. The power of single-cell RNA sequencing offers various opportunities to decipher
Andrés Noé, Tamsin N. Cargill, Carolyn M. Nielsen, Andrew J. C. Russell, Eleanor Barnes   +4 more
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Pumping the brakes on RNA velocity by understanding and interpreting RNA velocity estimates

Genome Biology, 2023
Background RNA velocity analysis of single cells offers the potential to predict temporal dynamics from gene expression. In many systems, RNA velocity has been observed to produce a vector field that qualitatively reflects known features of the system ...
Shijie C. Zheng, Genevieve Stein-O’Brien, Leandros Boukas, Loyal A. Goff, Kasper D. Hansen   +4 more
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Delineating COVID-19 immunological features using single-cell RNA sequencing

The Innovation, 2022
Understanding the molecular mechanisms of coronavirus disease 2019 (COVID-19) pathogenesis and immune response is vital for developing therapies. Single-cell RNA sequencing has been applied to delineate the cellular heterogeneity of the host response ...
Wendao Liu, Johnathan Jia, Yulin Dai, Wenhao Chen, Guangsheng Pei, Qiheng Yan, Zhongming Zhao   +6 more
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Single cell RNA sequencing research in maternal fetal interface

Frontiers in Cell and Developmental Biology, 2023
The maternal-fetal interface is an essential environment for embryonic growth and development, and a successful pregnancy depends on the dynamic balance of the microenvironment at the maternal-fetal interface.
Qian Chen, Qian Chen, Dan Shan, Dan Shan, Yupei Xie, Yupei Xie, Xingrong Luo, Xingrong Luo, Yuxia Wu, Yuxia Wu, Qiuhe Chen, Qiuhe Chen, Ruihong Dong, Ruihong Dong, Yayi Hu, Yayi Hu, Yayi Hu   +16 more
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Single-cell RNA-sequencing of the brain

Clinical and Translational Medicine, 2017
Single-cell RNA-sequencing (scRNA-seq) is revolutionizing our understanding of the genomic, transcriptomic and epigenomic landscapes of cells within organs.
Raquel Cuevas-Diaz Duran, Haichao Wei, Jia Qian Wu   +2 more
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