Results 61 to 70 of about 1,198,587 (324)
SAVER: Gene expression recovery for single-cell RNA sequencing
Nature Methods, 2018 In single-cell RNA sequencing (scRNA-seq) studies, only a small fraction of the transcripts present in each cell are sequenced. This leads to unreliable quantification of genes with low or moderate expression, which hinders downstream analysis.
Mo Huang +9 more
semanticscholar +1 more source
Observation weights unlock bulk RNA-seq tools for zero inflation and single-cell applications [PDF]
, 2018 Dropout events in single-cell RNA sequencing (scRNA-seq) cause many transcripts to go undetected and induce an excess of zero read counts, leading to power issues in differential expression (DE) analysis.
Clement, Lieven +8 more
core +7 more sources
Comparative Analysis of Single-Cell RNA Sequencing Methods [PDF]
Molecular Cell, 2017 Single-cell RNA sequencing (scRNA-seq) offers new possibilities to address biological and medical questions. However, systematic comparisons of the performance of diverse scRNA-seq protocols are lacking. We generated data from 583 mouse embryonic stem cells to evaluate six prominent scRNA-seq methods: CEL-seq2, Drop-seq, MARS-seq, SCRB-seq, Smart-seq ...
Ziegenhain, Christoph +9 more
openaire +3 more sources
bioRxiv, 2020 The new coronavirus (2019-nCoV) outbreak from December 2019 in Wuhan, Hubei, China, has been declared a global public health emergency. Angiotensin I converting enzyme 2 (ACE2), is the host receptor by 2019-nCov to infect human cells.
Furong Qi +3 more
semanticscholar +1 more source
bioRxiv, 2018 Microglia are increasingly recognized for their major contributions during brain development and neurodegenerative disease. It is currently unknown if these functions are carried out by subsets of microglia during different stages of development and ...
Qingyun Li +14 more
semanticscholar +1 more source
Science Advances, 2020 Single-cell RNA sequencing provides new insights into pathologic epithelial and mesenchymal remodeling in the human lung. Pulmonary fibrosis (PF) is a form of chronic lung disease characterized by pathologic epithelial remodeling and accumulation of ...
A. C. Habermann +27 more
semanticscholar +1 more source
Molecular recording of mammalian embryogenesis. [PDF]
, 2019 Ontogeny describes the emergence of complex multicellular organisms from single totipotent cells. This field is particularly challenging in mammals, owing to the indeterminate relationship between self-renewal and differentiation, variation in progenitor
Adamson, Britt +13 more
core +2 more sources
Power Analysis of Single Cell RNA-Sequencing Experiments [PDF]
Nature Methods, 2016 AbstractHigh-throughput single cell RNA sequencing (scRNA-seq) has become an established and powerful method to investigate transcriptomic cell-to-cell variation, and has revealed new cell types, and new insights into developmental process and stochasticity in gene expression.
Svensson, Valentine +7 more
openaire +4 more sources
Continual learning approaches for single cell RNA sequencing data
Scientific Reports, 2023 Single-cell RNA sequencing data is among the most interesting and impactful data of today and the sizes of the available datasets are increasing drastically.
Gorkem Saygili, Busra OzgodeYigin
doaj +1 more source
Single cell RNA sequencing of human microglia uncovers a subset associated with Alzheimer’s disease
Nature Communications, 2020 The extent of microglial heterogeneity in humans remains a central yet poorly explored question in light of the development of therapies targeting this cell type.
M. Olah +26 more
semanticscholar +1 more source