Results 21 to 30 of about 731,457 (305)
Single‐cell
Cell Proliferation, 2023 AbstractOsteoarthritis is a progressive and heterogeneous joint disease with complex pathogenesis. The various phenotypes associated with each patient suggest that better subgrouping of tissues associated with genotypes in different phases of osteoarthritis may provide new insights into the onset and progression of the disease.
Yuyuan Gu +5 more
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Recent advances in deciphering hippocampus complexity using single-cell transcriptomics
Neurobiology of Disease, 2023 Single-cell and single-nucleus RNA sequencing (scRNA-seq and snRNA-seq) technologies have emerged as revolutionary and powerful tools, which have helped in achieving significant progress in biomedical research over the last decade.
Chenxu Chang, Hongyan Zuo, Yang Li
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Single-cell RNA sequencing of human kidney [PDF]
Scientific Data, 2020 AbstractA comprehensive cellular anatomy of normal human kidney is crucial to address the cellular origins of renal disease and renal cancer. Some kidney diseases may be cell type-specific, especially renal tubular cells. To investigate the classification and transcriptomic information of the human kidney, we rapidly obtained a single-cell suspension ...
Liao, Jinling +11 more
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Single-cell RNA-sequencing of RVFV infection
On the RNA level, viral infections are characterized by perturbations in the host cell transcriptome as well as the development of viral genetic information.
Wyler, E.
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Overview of single‐cell RNA sequencing analysis and its application to spermatogenesis research
Reproductive Medicine and Biology, 2023 Background Single‐cell transcriptomics allows parallel analysis of multiple cell types in tissues. Because testes comprise somatic cells and germ cells at various stages of spermatogenesis, single‐cell RNA sequencing is a powerful tool for investigating ...
Takahiro Suzuki
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Genome Biology, 2023 Deconvolution of cell mixtures in “bulk” transcriptomic samples from homogenate human tissue is important for understanding disease pathologies. However, several experimental and computational challenges impede transcriptomics-based deconvolution ...
Sean K. Maden +5 more
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Application of single-cell RNA sequencing technologies in aortic dilatation diseases [PDF]
Jichu yixue yu linchuang, 2022 Aortic dilation disease, represented by aortic dissection and aortic aneurysm, is the most dangerous disease in vascular surgery. The pathogenesis of this disease is not very clear.
ZHENG Kai, REN Hua-liang, ZHANG Wang-de, LI Chun-min
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Single-cell RNA Sequencing in Immunology
Current Genomics, 2020 The complex immune system is involved in multiple pathological processes. Single-cell RNA sequencing (scRNA-seq) is able to analyze complex cell mixtures correct to a single cell and single molecule, thus is qualified to analyze immune reactions in several diseases.
Yirui Cao +3 more
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Single Cell RNA Sequencing in Atherosclerosis Research [PDF]
Circulation Research, 2020 Technological advances in characterizing molecular heterogeneity at the single cell level have ushered in a deeper understanding of the biological diversity of cells present in tissues including atherosclerotic plaques. New subsets of cells have been discovered among cell types previously considered homogenous. The commercial availability of systems to
Jesse W. Williams +5 more
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Crafting a blueprint for single-cell RNA sequencing [PDF]
Trends in Plant Science, 2022 Droplet-based single-cell RNA sequencing (scRNA-Seq) has moved rapidly from a technology with great potential to a method applied to ever-broader questions. The detailed information that scRNA-Seq offers has proven incredibly powerful in resolving cell responses to developmental and environmental cues.
Tom Denyer, Marja C.P. Timmermans
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