Results 11 to 20 of about 731,457 (305)

The Application of Single-Cell RNA Sequencing in Vaccinology [PDF]

Journal of Immunology Research, 2020
Single-cell RNA sequencing allows highly detailed profiling of cellular immune responses from limited-volume samples, advancing prospects of a new era of systems immunology. The power of single-cell RNA sequencing offers various opportunities to decipher
Andrés Noé, Tamsin N. Cargill, Carolyn M. Nielsen, Andrew J. C. Russell, Eleanor Barnes   +4 more
doaj   +5 more sources

Single-cell RNA-sequencing of the brain [PDF]

Clinical and Translational Medicine, 2017
Single-cell RNA-sequencing (scRNA-seq) is revolutionizing our understanding of the genomic, transcriptomic and epigenomic landscapes of cells within organs.
Raquel Cuevas-Diaz Duran, Haichao Wei, Jia Qian Wu   +2 more
doaj   +3 more sources

Single‐cell RNA sequencing in cancer research [PDF]

Journal of Experimental & Clinical Cancer Research, 2021
Single-cell RNA sequencing (scRNA-seq), a technology that analyzes transcriptomes of complex tissues at single-cell levels, can identify differential gene expression and epigenetic factors caused by mutations in unicellular genomes, as well as new cell ...
Yijie Zhang, Dan Wang, Miao Peng, Le Tang, Jiawei Ouyang, Fang Xiong, Can Guo, Yanyan Tang, Yujuan Zhou, Qianjin Liao, Xu Wu, Hui Wang, Jianjun Yu, Yong Li, Xiaoling Li, Guiyuan Li, Zhaoyang Zeng, Yixin Tan, Wei Xiong   +18 more
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SMARTer single cell total RNA sequencing [PDF]

Nucleic Acids Research, 2019
Single cell RNA sequencing methods have been increasingly used to understand cellular heterogeneity. Nevertheless, most of these methods suffer from one or more limitations, such as focusing only on polyadenylated RNA, sequencing of only the 3' end of ...
Livak, Kenneth, Kjems, Jørgen, Speleman, Franki, Vandesompele, Jo, Lee, Simon, Yigit, Nurten, Rombaut, Dries, Bolduc, Nathalie, Mestdagh, Pieter, Venø, Morten, Everaert, Celine, Verboom, Karen, Anckaert, Jasper   +12 more
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From bulk, single-cell to spatial RNA sequencing [PDF]

International Journal of Oral Science, 2021
RNA sequencing (RNAseq) can reveal gene fusions, splicing variants, mutations/indels in addition to differential gene expression, thus providing a more complete genetic picture than DNA sequencing.
Xinmin Li, Cun-Yu Wang
doaj   +2 more sources

Single-Cell RNA Sequencing Reveals Peripheral Immune Cell Senescence and Inflammatory Phenotypes in Patients with Premature Ovarian Failure

Journal of Inflammation Research
Jianan Liu,1 Li Wang,2 Weijun Zhong,1 Jing Cai,3 Yan Sun,3 SongJun Li,2 Jiayi Li,4 Yanhui Liu,2 Fu Xiong1,5,6 1Department of Medical Genetics/Experimental Education/Administration Center, School of Basic Medical Sciences, Southern Medical University ...
Liu J, Wang L, Zhong W, Cai J, Sun Y, Li S, Li J, Liu Y, Xiong F   +8 more
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Editorial: Deciphering cardiovascular cell heterogeneity with single cell RNA sequencing [PDF]

Frontiers in Medicine
Paolo Madeddu, Ngan F. Huang, Ngan F. Huang, Ngan F. Huang, Ngan F. Huang   +4 more
doaj   +2 more sources

Single-cell RNA sequencing technologies and bioinformatics pipelines

Experimental and Molecular Medicine, 2018
Genetic data: Zooming in on single cells Showing which genes are expressed, or switched on, in individual cells may help to reveal the first signs of disease.
Byungjin Hwang, Ji Hyun Lee, Duhee Bang
doaj   +3 more sources

Advances in application of single-cell RNA sequencing in cardiovascular research

Frontiers in Cardiovascular Medicine, 2022
Single-cell RNA sequencing (scRNA-seq) provides high-resolution information on transcriptomic changes at the single-cell level, which is of great significance for distinguishing cell subtypes, identifying stem cell differentiation processes, and ...
Yue Hu, Ying Zhang, Yutong Liu, Yan Gao, Tiantian San, Xiaoying Li, Xiaoying Li, Sensen Song, Binglong Yan, Zhuo Zhao, Zhuo Zhao   +10 more
doaj   +1 more source

Transcriptomics and single‐cell RNA‐sequencing [PDF]

Respirology, 2018
ABSTRACTThe past four decades have yielded advances in molecular biology allowing detailed characterization of the cellular genome and the transcriptome: the complete set of RNA species transcribed by a cell or tissue. Through transcriptomics and next‐generation sequencing, we can now attain an unprecedented level of detail in understanding cellular ...
Daniel C. Chambers, Alan M. Carew, Samuel W. Lukowski, Joseph E. Powell   +3 more
openaire   +5 more sources