Results 11 to 20 of about 1,215,495 (340)

Single-cell RNA-sequencing in asthma research

Frontiers in Immunology, 2022
Asthma is a complex and heterogeneous disease with multicellular involvement, and knowledge gaps remain in our understanding of the pathogenesis of asthma. Efforts are still being made to investigate the immune pathogenesis of asthma in order to identify
Weifeng Tang, Weifeng Tang, Mihui Li, Mihui Li, Fangzhou Teng, Fangzhou Teng, Jie Cui, Jie Cui, Jingcheng Dong, Jingcheng Dong, Wenqian Wang, Wenqian Wang   +11 more
doaj   +3 more sources

Clinical Perspectives of Single-Cell RNA Sequencing [PDF]

Biomolecules, 2021
The ability of single-cell genomics to resolve cellular heterogeneity is highly appreciated in cancer and is being exploited for precision medicine. In the recent decade, we have witnessed the incorporation of cancer genomics into the clinical decision ...
Nayoung Kim, Hye Hyeon Eum, Hae-Ock Lee
doaj   +3 more sources

Single-cell RNA sequencing in orthopedic research

Bone Research, 2023
Although previous RNA sequencing methods have been widely used in orthopedic research and have provided ideas for therapeutic strategies, the specific mechanisms of some orthopedic disorders, including osteoarthritis, lumbar disc herniation, rheumatoid ...
Tao Wang, Ling Wang, Liping Zhang, Yubin Long, Yingze Zhang, Zhiyong Hou   +5 more
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Single-Cell RNA Sequencing in Parkinson’s Disease [PDF]

Biomedicines, 2021
Single-cell and single-nucleus RNA sequencing (sc/snRNA-seq) technologies have enhanced the understanding of the molecular pathogenesis of neurodegenerative disorders, including Parkinson’s disease (PD).
Shi-Xun Ma, Su Bin Lim
doaj   +3 more sources

Single-cell RNA-sequencing of the brain [PDF]

Clinical and Translational Medicine, 2017
Single-cell RNA-sequencing (scRNA-seq) is revolutionizing our understanding of the genomic, transcriptomic and epigenomic landscapes of cells within organs.
Raquel Cuevas-Diaz Duran, Haichao Wei, Jia Qian Wu   +2 more
doaj   +3 more sources

scDA: Single cell discriminant analysis for single-cell RNA sequencing data

Computational and Structural Biotechnology Journal, 2021
Single-cell RNA-sequencing (scRNA-seq) techniques provide unprecedented opportunities to investigate phenotypic and molecular heterogeneity in complex biological systems.
Qianqian Shi, Xinxing Li, Qirui Peng, Chuanchao Zhang, Luonan Chen   +4 more
doaj   +3 more sources

Therapy-Induced Evolution of Human Lung Cancer Revealed by Single-Cell RNA Sequencing

Cell, 2020
Summary Lung cancer, the leading cause of cancer mortality, exhibits heterogeneity that enables adaptability, limits therapeutic success, and remains incompletely understood.
A. Maynard, C. McCoach, J. Rotow, Lincoln Harris, Franziska Haderk, D. Kerr, Elizabeth A. Yu, Erin L. Schenk, Weilun Tan, Alexander Zee, Michelle Tan, Philippe Gui, T. Lea, Wei Wu, A. Urisman, K. Jones, R. Sit, P. Kolli, E. Seeley, Y. Gesthalter, Daniel D. Le, K. Yamauchi, D. Naeger, Sourav Bandyopadhyay, K. Shah, Lauren Cech, Nicholas J. Thomas, Anshal Gupta, Mayra Gonzalez, Hien Do, L. Tan, Bianca Bacaltos, Rafael Gomez-Sjoberg, M. Gubens, T. Jahan, J. Kratz, D. Jablons, N. Neff, R. Doebele, J. Weissman, C. Blakely, S. Darmanis, T. Bivona   +42 more
semanticscholar   +3 more sources

Single‐Cell RNA Sequencing of Microglia throughout the Mouse Lifespan and in the Injured Brain Reveals Complex Cell‐State Changes

Immunity, 2019
Summary Microglia, the resident immune cells of the brain, rapidly change states in response to their environment, but we lack molecular and functional signatures of different microglial populations.
Timothy R. Hammond, Connor Dufort, Lasse Dissing‐Olesen, Stefanie Giera, Adam M. H. Young, Alec Wysoker, A. Walker, Frederick W. Gergits, Michael Segel, J. Nemesh, S. Marsh, Arpiar Saunders, Evan Z. Macosko, F. Ginhoux, Jinmiao Chen, R. Franklin, X. Piao, S. Mccarroll, B. Stevens   +18 more
semanticscholar   +3 more sources

SAVER: Gene expression recovery for single-cell RNA sequencing

Nature Methods, 2018
In single-cell RNA sequencing (scRNA-seq) studies, only a small fraction of the transcripts present in each cell are sequenced. This leads to unreliable quantification of genes with low or moderate expression, which hinders downstream analysis.
Mo Huang, Jingshu Wang, E. Torre, Hannah Dueck, Sydney M. Shaffer, R. Bonasio, J. Murray, A. Raj, Mingyao Li, Nancy R. Zhang   +9 more
semanticscholar   +3 more sources

From bulk, single-cell to spatial RNA sequencing [PDF]

International Journal of Oral Science, 2021
RNA sequencing (RNAseq) can reveal gene fusions, splicing variants, mutations/indels in addition to differential gene expression, thus providing a more complete genetic picture than DNA sequencing.
Xinmin Li, Cun-Yu Wang
doaj   +5 more sources