Results 51 to 60 of about 731,457 (305)
Continual learning approaches for single cell RNA sequencing data
Scientific Reports, 2023 Single-cell RNA sequencing data is among the most interesting and impactful data of today and the sizes of the available datasets are increasing drastically.
Gorkem Saygili, Busra OzgodeYigin
doaj +1 more source
, 2023 The structure and major cell types of the multi-layer human cornea have been extensively studied. However, various cell states in specific cell types and key genes that define the cell states are not fully understood, hindering our comprehension of ...
Dulce Lima Cunha +3 more
core +1 more source
FEATS: feature selection-based clustering of single-cell RNA-seq data
, 2021 MOTIVATION: Advances in next-generation sequencing have made it possible to carry out transcriptomic studies at single-cell resolution and generate vast amounts of single-cell RNA sequencing (RNA-seq) data rapidly.
Vans, E, Patil, A, Sharma, A
core +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Single-cell isolation by a modular single-cell pipette for RNA-sequencing [PDF]
Lab on a Chip, 2016 We report a modular single-cell pipette (mSCP), consisting of an air-displacement pipette (ADP), ADP-Tips, and a SCP-Tip, and its application in single-cell isolation for RNA-sequencing.
Kai Zhang +6 more
openaire +2 more sources
Single-Cell RNA-Sequencing: Assessment of Differential Expression Analysis Methods
Frontiers in Genetics, 2017 The sequencing of the transcriptomes of single-cells, or single-cell RNA-sequencing, has now become the dominant technology for the identification of novel cell types and for the study of stochastic gene expression.
Alessandra Dal Molin +2 more
doaj +1 more source
CRISPR screening in single cells
, 2019 The combination of single-cell RNA-seq and CRISPR allows for efficient interrogation of possibly any number of genes, only limited by the sequencing capability. Here we describe the current protocols for CRISPR screening in single cells, from cloning and
Henriksson, Johan,
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Deciphering Cell Lineage Specification during Male Sex Determination with Single-Cell RNA Sequencing [PDF]
, 2017 Summary: The gonad is a unique biological system for studying cell-fate decisions. However, major questions remain regarding the identity of somatic progenitor cells and the transcriptional events driving cell differentiation.
Emmanouil T. Dermitzakis +28 more
core +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Single Cell RNA-Sequencing for the Study of Atherosclerosis
Journal of Lipid and Atherosclerosis, 2019 Atherosclerosis is a major cause of coronary artery disease and stroke. A massive and new type of data has finally arrived in the field of atherosclerosis: single cell RNA sequencing (scRNAseq). Recently, scRNAseq has been successfully applied to the study of atherosclerosis to identify previously uncharacterized cell populations.
Morteza Chalabi Hajkarim, Kyoung Jae Won
openaire +4 more sources