Results 241 to 250 of about 4,782 (272)

Herb‐Based Extracellular Vesicles for Infectious Disease

Small Structures, Volume 7, Issue 5, May 2026.
Chinese herbal medicine‐derived extracellular vesicles‐like particles (CHM‐EVLPs) are presented as innovative nanomedicines for infectious diseases. This review highlights their diverse therapeutic effects, including pathogen clearance, immune modulation, microbiota regulation and tissue barrier repairment, unlocking a powerful natural material against
Erjia Weng, Zhi‐Chao Sun, Yuntao Liu, Ran Liao, Ran Lin, Yan Zhang, Xi Zhang, Minghua Tang, Kaichun Yang, Xiaolu Wang, Wen Huang, Zhongde Zhang, Xiaotu Xi, Jun Wu   +13 more
wiley   +1 more source

Allogenic blood patch pleurodesis for management of presumptive secondary spontaneous pneumothorax in a cat

Veterinary Record Case Reports, Volume 14, Issue 2, May 2026.
Abstract A 7‐year‐old spayed female domestic shorthair cat was presented with respiratory distress due to presumed spontaneous pneumothorax. High‐resolution computed tomography identified subpleural blebs and paraseptal emphysema with peribronchial thickening and bronchiectasis.
Jihyun Han, Jeongmin Lee, Kyoung‐A Youp, Heetae Park, Jinhwa Chang, Gippeum Lee   +5 more
wiley   +1 more source

UNC45B Reduction With Aging: A Myofiber‐Intrinsic Promoting Factor for Sarcopenia

Aging Cell, Volume 25, Issue 5, May 2026.
Aging reduces Unc45b expression in fast‐twitch muscle, concomitant with reduction in muscle contractile capacity and muscle mass in mice. Unc45b deficiency initially reduces depolarization‐induced force, followed by a decline in fast‐twitch muscle mass in adult mice.
Taiga Mishima, Taiga Nagamune, Saori Tada, Daiki Watanabe, Nao Tokuda, Takashi Yamada, Akiko Hashimoto‐Hachiya, Sayaka Higo‐Yamamoto, Kohei Kido, Noriyuki Nagaoka, Aoi Ikedo, Yuuki Imai, Ryo Fujita, Seiya Mizuno, Satoru Takahashi, Katsutaka Oishi, Satoru Ato, Riki Ogasawara   +17 more
wiley   +1 more source

Population Pharmacokinetics and Pharmacodynamics of GSK961081 (Batefenterol), a Muscarinic Antagonist and β-Agonist, in Moderate-to-Severe COPD Patients: Substudy of a Randomized Trial [PDF]

core   +1 more source

Critical role of the mast cell/tryptase/PAR2 axis in anastrozole‐induced pain

British Journal of Pharmacology, Volume 183, Issue 9, Page 2009-2027, May 2026.
Abstract Background and Purpose Anastrozole, an aromatase inhibitor, is used to treat postmenopausal women with hormone receptor‐positive breast cancer, but also induces musculoskeletal pain and can lead to therapeutic regimen suspension. Aromatase inhibitors promote the release of pro‐inflammatory substances from sensitised nerve fibres, which might ...
Maria Fernanda Pessano Fialho, Raquel Tonello, Evelyne Silva Brum, Gabriela Becker, Nigel W. Bunnett, Sara Marchesan Oliveira   +5 more
wiley   +1 more source

Pharmacological inhibition of hydroxysteroid 11‐beta dehydrogenase type 1 (11‐βHSD1) after myocardial infarction preserves cardiac function in a translational mini‐pig model

British Journal of Pharmacology, Volume 183, Issue 10, Page 2236-2255, May 2026.
Abstract Background and Purpose Plasma glucocorticoids increase acutely after MI, thereafter tissue levels are amplified selectively within cells expressing 11‐ßhydroxysteroid dehydrogenase type 1 (11‐ßHSD1) that regenerates active glucocorticoids from circulating metabolites.
Sara Al Disi, Raimondo Ascione, Shazia Khan, Thomas Johnson, Eva Sammut, Vito Domenico Bruno, Daniel Baz Lopez, Carol‐Anne James, Joanna Simpson, Natalie Z. Homer, Michael Millar, Trisha Singh, Alex von Kreigsheim, Nick L. Mills, Brian R. Walker, Ruth Andrew, Scott P. Webster, Andrew Whittaker, Adrian Freeman, Gillian A. Gray   +19 more
wiley   +1 more source

Matsupexole: A novel nonergot dopamine receptor agonist with sustained efficacy in a rat model of Parkinson's disease and limited off‐target activity

British Journal of Pharmacology, Volume 183, Issue 10, Page 2518-2532, May 2026.
Background and Purpose Dopamine receptor agonists, particularly targeting the dopamine D2L receptor (D2LR), have been used to treat Parkinson's disease (PD). However, valvular heart disease and somnolence, mainly caused by activating the serotonin 5‐HT2B receptor (5‐HT2BR) and dopamine D3 receptor (D3R), respectively, currently challenge their clinical
Takayuki Suzuki, Fumiki Oana, Masaki Oota, Yuma Handa, Osamu Kaminuma   +4 more
wiley   +1 more source

Educational Outcomes Associated With Undergraduate Dental Education in Primary Care and Community Settings in Europe: Findings From a Rapid Scoping Review

European Journal of Dental Education, Volume 30, Issue 2, Page 578-589, May 2026.
ABSTRACT Background Recent decades have seen the emergence of primary care and community (PCC) based dental education in settings that are separate to dental teaching hospitals, including general dental practice and salaried dental services. By mirroring care delivery in these services, this experience can facilitate students' transition to independent
Paul Leavy, Blánaid Daly
wiley   +1 more source

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A single inhaler triple therapy fluticasone furoate/umeclidinium/vilanterol for the treatment of COPD

Expert Review of Clinical Pharmacology, 2022
Single inhaler triple therapy (SITT) with an inhaled corticosteroid, a long-acting β2-agonist, and a long-acting muscarinic antagonist is an effective and attractive therapeutic option codified in the recommendations of guidelines and treatment strategies for the management of COPD.The preclinical and clinical development in COPD of fluticasone furoate
Mario Cazzola, Paola Rogliani, Luigino Calzetta   +2 more
exaly   +4 more sources

Efficacy and Safety of Single Inhaler Triple Therapy Versus Separate Triple Therapy in Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-analysis

Clinical Therapeutics, 2022
This study aimed to compare the efficacy and safety of single inhaler triple therapy and separate triple therapy in the treatment of patients with moderate to severe chronic obstructive pulmonary disease (COPD).PubMed, Embase, Web of Science, Cochrane Library, and ClinicalTrials.gov databases were searched, and the search date was set from database ...
Liansheng, Zhang, Xiaoqing, Wang, Ye, Zhang, Wenyu, Chen   +3 more
exaly   +3 more sources